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[颅骨骨-硬膜重建材料。最新进展]

[Materials for osteo-dural reconstruction in the cranium. An update].

作者信息

George B, Jamet P, Frerebeau P, Clemenceau S, Keravel Y, Ducolombier A, Tadie M, Lagarrigue J, Peragut J C, Fawas A

机构信息

Service de Neurochirurgie, Hôpital Lariboisière, Paris.

出版信息

Neurochirurgie. 1989;35(3):145-51.

PMID:2695852
Abstract

Materials available for repair of a bony or dural defect at the cranial level are reviewed with particular attention stressed on their qualities and drawbacks for neurosurgical purposes. These materials include autologous or heterologous bone graft and biologically stable or biodegradable implants. No material can demonstrate ideal qualities of biocompatibility and biofunctionality. It should be either perfectly stable biologically and inert or perfectly biodegradable allowing simultaneous new bone reconstruction; moreover, it should be sterilizable, disposable, easy to handle and of low cost. Autologous grafts (iliac bone, split bone flap, pericranium...) have the best features but irradiated heterologous bone can be used instead; the latter needs a particular organization (bone graft bank) to fill the strict conditions of safety, especially regarding the risks of virus transmission. Implants have more recently been developed (acrylic, coral, B.O.P., ceramic, collagen-vicryl...) and present some drawbacks: generally high cost and not well established or insufficient biological properties. The experience of French neurosurgeons is reported from a questionnaire (102 answers) on the most frequently used materials. Autologous bone grafts, and acrylic as bone substitutes and pericranium for dural repair are preferentially used. Some materials, including coral, B.O.P. and collagen-vicryl, have a decreasing utilisation because of poor results especially with regards to bone incorporation and water tightness. Particular techniques (acrylic + teflon, acrylic with pre-op external casting and even non-repair of bone defects) are proposed by some neurosurgeons. New materials still under experimentation are finally presented (lyophilized bovine pericardium, collagen IV, polylactic acid).

摘要

本文综述了可用于修复颅骨水平骨缺损或硬脑膜缺损的材料,特别强调了其在神经外科手术中的优缺点。这些材料包括自体或异体骨移植以及生物稳定或可生物降解的植入物。没有一种材料能具备理想的生物相容性和生物功能性。它要么在生物学上完全稳定且惰性,要么完全可生物降解并能同时实现新骨重建;此外,它应可消毒、一次性使用、易于操作且成本低廉。自体移植材料(髂骨、劈开的骨瓣、颅骨膜……)具有最佳特性,但也可使用经辐照的异体骨;后者需要特定的组织(骨库)来满足严格的安全条件,尤其是关于病毒传播风险的条件。近年来已开发出多种植入物(丙烯酸、珊瑚、B.O.P.、陶瓷、胶原 - 维克ryl……),但存在一些缺点:通常成本高昂且生物学特性尚未充分确立或不完善。通过一份问卷(102份回复)报告了法国神经外科医生在最常用材料方面的经验。优先使用自体骨移植、作为骨替代物的丙烯酸以及用于硬脑膜修复的颅骨膜。一些材料,包括珊瑚、B.O.P.和胶原 - 维克ryl,由于效果不佳,尤其是在骨整合和水密性方面,其使用频率正在下降。一些神经外科医生提出了特定技术(丙烯酸 + 特氟龙、术前外部塑形的丙烯酸,甚至不修复骨缺损)。最后介绍了仍在试验中的新材料(冻干牛心包、IV型胶原、聚乳酸)。

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