常见单核苷酸多态性与亚临床动脉粥样硬化之间关联的详细分析：动脉粥样硬化多族裔研究
Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis.
作者信息
Vargas Jose D, Manichaikul Ani, Wang Xin-Qun, Rich Stephen S, Rotter Jerome I, Post Wendy S, Polak Joseph F, Budoff Matthew J, Bluemke David A
机构信息
MedStar Health Research Institute, Georgetown University Hospital, Washington, District of Columbia, USA; National Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA.
Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA; Center for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
出版信息
Data Brief. 2016 Feb 15;7:229-42. doi: 10.1016/j.dib.2016.01.048. eCollection 2016 Jun.
Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included.
在主要为欧洲血统的参与者中，针对先前在心血管疾病（CVD）全基因组关联研究（GWAS）中鉴定出的单核苷酸多态性（SNP），在动脉粥样硬化多民族研究（MESA）中测试其与亚临床心血管疾病（sCVD）、冠状动脉钙化评分（CAC）和颈动脉内膜中层厚度（CIMT）的关联性。本简要数据文章中的数据对应于《常见基因变异与亚临床动脉粥样硬化：动脉粥样硬化多民族研究》[1]一文。本文包括该文中分析的参与者的人口统计学信息，以及所选SNP与CAC关联性的图形展示和数据表，还有跨种族CIMT-c（颈总动脉）、CIMT-I（颈内动脉）、CAC-d（CAC作为二分变量，CAC>0）和CAC-c（CAC作为连续变量，原始CAC评分加1的对数）与CVD关联性的荟萃分析。还包括与9p21精细定位实验对应的数据表以及该文中引用的功效计算。
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