K-Ras at Anionic Membranes: Orientation, Orientation…Orientation. Recent Simulations and Experiments.
作者信息
Li ZhenLu, Cao Shufen, Buck Matthias
机构信息
Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio.
Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio; Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio; Case Comprehensive Cancer Center, Case Western Reserve University, School of Medicine, Cleveland, Ohio; Center for Proteomics and Bioinformatics, Case Western Reserve University, School of Medicine, Cleveland, Ohio.
出版信息
Biophys J. 2016 Mar 8;110(5):1033-5. doi: 10.1016/j.bpj.2016.01.020.
Abstract
摘要
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Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.致癌性K-Ras以两种不同取向与阴离子膜结合：分子动力学分析。
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2
GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.GTP结合与致癌突变可能减弱小GTP酶K-Ras4B中高变区（HVR）-催化结构域的相互作用，从而暴露效应器结合位点。
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Structure. 2015 Jul 7;23(7):1325-35. doi: 10.1016/j.str.2015.04.019. Epub 2015 Jun 4.
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