Lee In-Chul, Choi Bu Young
Department of Cosmetic science, Seowon University, Cheongju, Chungbuk 361-742, Korea.
Department of Pharmaceutical Science & Engineering, Seowon University, Cheongju, Chungbuk 361-742, Korea.
Int J Mol Sci. 2016 Mar 4;17(3):290. doi: 10.3390/ijms17030290.
Cancer, being the second leading cause of mortality, exists as a formidable health challenge. In spite of our enormous efforts, the emerging complexities in the molecular nature of disease progression limit the real success in finding an effective cancer cure. It is now conceivable that cancer is, in fact, a progressive illness, and the morbidity and mortality from cancer can be reduced by interfering with various oncogenic signaling pathways. A wide variety of structurally diverse classes of bioactive phytochemicals have been shown to exert anticancer effects in a large number of preclinical studies. Multiple lines of evidence suggest that withaferin-A can prevent the development of cancers of various histotypes. Accumulating data from different rodent models and cell culture experiments have revealed that withaferin-A suppresses experimentally induced carcinogenesis, largely by virtue of its potent anti-oxidative, anti-inflammatory, anti-proliferative and apoptosis-inducing properties. Moreover, withaferin-A sensitizes resistant cancer cells to existing chemotherapeutic agents. The purpose of this review is to highlight the mechanistic aspects underlying anticancer effects of withaferin-A.
癌症作为第二大致死原因，是一项严峻的健康挑战。尽管我们付出了巨大努力，但疾病进展分子本质中不断出现的复杂性限制了找到有效癌症治疗方法的实际成效。现在可以想象，癌症实际上是一种进行性疾病，通过干扰各种致癌信号通路可以降低癌症的发病率和死亡率。在大量临床前研究中，已证明多种结构多样的生物活性植物化学物质具有抗癌作用。多条证据表明，睡茄内酯A可以预防各种组织类型癌症的发生。来自不同啮齿动物模型和细胞培养实验的越来越多的数据表明，睡茄内酯A主要凭借其强大的抗氧化、抗炎、抗增殖和诱导凋亡特性，抑制实验诱导的致癌作用。此外，睡茄内酯A使耐药癌细胞对现有化疗药物敏感。本综述的目的是强调睡茄内酯A抗癌作用背后的机制方面。
