a Centre of Biomedical Research, SGPGIMS Campus , Lucknow , UP , India.
b Department of Radiology , University of Pennsylvania , Philadelphia , PA , USA.
Expert Rev Mol Diagn. 2016 Jun;16(6):651-61. doi: 10.1586/14737159.2016.1164037. Epub 2016 Mar 25.
Advances in the application of NMR spectroscopy-based metabolomic profiling of prostate cancer comprises a potential tactic for understanding the impaired biochemical pathways arising due to a disease evolvement and progression. This technique involves qualitative and quantitative estimation of plethora of small molecular weight metabolites of body fluids or tissues using state-of-the-art chemometric methods delivering an important platform for translational research from basic to clinical, to reveal the pathophysiological snapshot in a single step. This review summarizes the present arrays and recent advancements in NMR-based metabolomics and a glimpse of currently used medical imaging tactics, with their role in clinical diagnosis of prostate cancer.
基于核磁共振波谱的前列腺癌代谢组学分析的应用进展，为研究疾病演变和发展过程中生化途径的损伤提供了一种潜在策略。该技术涉及使用最先进的化学计量学方法对体液或组织中大量的小分子代谢物进行定性和定量评估，为从基础到临床的转化研究提供了一个重要平台，可在单个步骤中揭示病理生理快照。本综述总结了目前基于核磁共振的代谢组学的方法和阵列，以及当前使用的医学成像策略的最新进展，及其在前列腺癌临床诊断中的作用。
