Sugawara Tomonori, Sawada Daisuke, Yanagihara Sae, Aoki Yumeko, Takehara Isao, Sugahara Hirosuke, Hirota Tatsuhiko, Nakamura Yasunori, Ishikawa Susumu
Core Technology Laboratories, Asahi Quality and Innovations, Ltd., 11-10, 5 Chome, Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-0206, Japan.
PI-Food Service Division, Clinical Support Corporation, 4-1, Nishi 8 Chome, Minami 1 jo, Chuo-ku, Sapporo-shi, Hokkaido 060-0061, Japan.
Microorganisms. 2020 Feb 22;8(2):304. doi: 10.3390/microorganisms8020304.
Despite the fact that gut microbiota is closely associated with obesity, few studies have focused on the influences of paraprobiotics as food ingredients on both obesity prevention and the gut microbial community. In this study, we evaluated the effects of fragmented CP1563 (CP1563) as a paraprobiotic for obesity prevention and investigated its effects on the gut microbial community in pre-obese subjects. One hundred sixty-nine healthy subjects with a body mass index from 25.0 to 29.9 kg/m ingested beverages with or without the fragmented CP1563 containing 10-hydroxyoctadecanoic acid (10-HOA) for 12 weeks. The changes in abdominal, total, visceral, and subcutaneous fatty areas were significantly lower in the CP1563-10-HOA group than in the placebo group at 12 weeks. Furthermore, 16S rRNA gene sequencing of fecal DNA revealed that the changes in the abundances of the genera and g were significantly greater in the CP1563-10-HOA group than in the placebo group, and the changes in the abundances of the genus was significantly smaller in the CP1563-10HOA group than in the placebo group. Our results showed that continuous ingestion of the fragmented CP1563 containing 10-HOA reduced abdominal body fat and affected the gut microbial community in pre-obese healthy subjects. Our findings may contribute to the understanding of the relationship between the anti-obesity effect of paraprobiotics and gut microbiota.
尽管肠道微生物群与肥胖密切相关，但很少有研究关注益生元作为食品成分对肥胖预防和肠道微生物群落的影响。在本研究中，我们评估了片段化CP1563（CP1563）作为预防肥胖的益生元的效果，并研究了其对肥胖前期受试者肠道微生物群落的影响。169名体重指数在25.0至29.9kg/m的健康受试者饮用含有或不含含10-羟基十八烷酸（10-HOA）的片段化CP1563的饮料，持续12周。在12周时，CP1563-10-HOA组的腹部、总体、内脏和皮下脂肪面积变化显著低于安慰剂组。此外，粪便DNA的16S rRNA基因测序显示，CP1563-10-HOA组中属和属丰度的变化显著大于安慰剂组，而CP1563-10-HOA组中属丰度的变化显著小于安慰剂组。我们的结果表明，持续摄入含10-HOA的片段化CP1563可减少肥胖前期健康受试者的腹部体脂并影响其肠道微生物群落。我们的发现可能有助于理解益生元的抗肥胖作用与肠道微生物群之间的关系。
