Gogia A, Raina V, Deo S V S, Shukla N K, Mohanti B K
Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
Indian J Cancer. 2015 Oct-Dec;52(4):526-9. doi: 10.4103/0019-509X.178399.
Male breast cancer (MBC) is a rare disease and accounts for 1% of all breast cancers. There is limited data on MBC from India. The aim of our study was to assess clinico-pathological parameters and outcome in MBC patients.
This analysis was carried out in 76 patients of MBC who were registered at Institute Rotary Cancer Hospital of All India Institute Of Medical Sciences between 1996 and 2012. Patients' records were retrospective reviewed and data obtained from the computer database using International Classification of Diseases code (C-50).
The median age was 59 years (range: 28-80). The median duration of symptoms was 11 months (range: 0.5-40). Breast lump was the most common presenting symptom (left > right side). American Joint Committee on Cancer (7th edition) stage distribution was Stage I-2.6%, Stage II-13.1%, Stage III-59.3% and Stage IV-25%. Modified radical mastectomy was the commonest surgical procedure. Moreover, 30% of tumors were high-grade and 70% had pathological node positive disease. Estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2)/neu positivity was 80% and 28%, respectively. Triple negative breast cancer constituted 19% of cases. With a median follow-up of 36 months, 3 years relapse free survival and overall survival was 60% and 80%. Advanced stage and visceral metastasis at baseline predicted poor outcome.
MBC constituted 0.8% at our institute. Our study population had a longer time to presentation, advanced disease at presentation, more HER2/neu positivity and triple negativity higher than the available literature.
男性乳腺癌（MBC）是一种罕见疾病，占所有乳腺癌的1%。来自印度的关于MBC的数据有限。我们研究的目的是评估MBC患者的临床病理参数及预后。
本分析纳入了1996年至2012年间在全印度医学科学研究所扶轮癌症医院登记的76例MBC患者。对患者记录进行回顾性审查，并使用国际疾病分类代码（C-50）从计算机数据库中获取数据。
中位年龄为59岁（范围：28 - 80岁）。症状持续时间的中位数为11个月（范围：0.5 - 40个月）。乳房肿块是最常见的首发症状（左侧>右侧）。美国癌症联合委员会（第7版）分期分布为：I期-2.6%，II期-13.1%，III期-59.3%，IV期-25%。改良根治性乳房切除术是最常见的手术方式。此外，30%的肿瘤为高级别，70%有病理淋巴结阳性疾病。雌激素受体、孕激素受体和人表皮生长因子受体2（HER2）/neu阳性率分别为80%和28%。三阴性乳腺癌占病例的19%。中位随访36个月，3年无复发生存率和总生存率分别为60%和80%。基线时的晚期阶段和内脏转移预示着不良预后。
在我们研究所，MBC占0.8%。我们的研究人群就诊时间较长，就诊时疾病处于晚期，HER2/neu阳性率和三阴性率高于现有文献。
