Videnović Goran, Illić Danijela, Miljus Dragan, Krasić Dragan, Vlahović Zoran, Zivković Snezana, Pavlović Aleksandar
Vojnosanit Pregl. 2016 Jan;73(1):53-8. doi: 10.2298/vsp141112023v.
BACKGROUND/AIM: Cancers of the lip, oral cavity and pharynx (LOCP) are frequently grouped together mainly because they have similar risk factors. The incidence rate of these cancers varies worldwide depending on the geographic location. The aim of this study was to determine trends in age-standardized incidence rates of LOCP cancers in the Belgrade population during a 12-year period, from 1999 to 2010.
From The Serbian Cancer Registry (The Registry), we extracted all cases of LOCP cancers registered in Belgrade from January 1, 1999 to December 31, 2010. Joinpoint regression analysis was used to define trends and annual percentage change (APC).
A total number of 2,025 (1,509 in men and 516 in women) LOCP cancers were reported to the Registry during the study period. The age standardized rate (ASR) for the entire period and for all LOCP cancers, was 6.24 per 100,000 persons (10.35 for men and 2.86 for women). ASR for lip cancers decreased (p < 0.001) during the study period with APC of -8.4%. The ASR for oral cavity and pharyngeal cancers increased (p < 0.05).
Our results show a significantly decreasing trend of the incidence rate for lip cancers in the population of the city of Belgrade between 1999 and 2010. On the contrary, the incidence of oral cavity and pharyngeal cancers increased for both men and women.
背景/目的：唇、口腔和咽癌（LOCP）常被归为一类，主要是因为它们有相似的风险因素。这些癌症的发病率在全球范围内因地理位置而异。本研究的目的是确定1999年至2010年这12年间贝尔格莱德人群中LOCP癌症年龄标准化发病率的趋势。
我们从塞尔维亚癌症登记处（登记处）提取了1999年1月1日至2010年12月31日在贝尔格莱德登记的所有LOCP癌症病例。采用Joinpoint回归分析来确定趋势和年度百分比变化（APC）。
在研究期间，登记处共报告了2025例LOCP癌症（男性1509例，女性516例）。整个时期所有LOCP癌症的年龄标准化率（ASR）为每10万人6.24例（男性为10.35例，女性为2.86例）。在研究期间，唇癌的ASR下降（p < 0.001），APC为-8.4%。口腔和咽癌的ASR上升（p < 0.05）。
我们的结果显示，1999年至2010年期间，贝尔格莱德市人群中唇癌的发病率呈显著下降趋势。相反，男性和女性的口腔和咽癌发病率均有所上升。
