Department of Population Health, Hofstra University, Hempstead, New York, USA.
Department of Environmental and Occupational Health, Texas A&M University, College Station, Texas, USA.
J Oral Pathol Med. 2022 Oct;51(9):763-770. doi: 10.1111/jop.13345. Epub 2022 Sep 7.
Changes in the epidemiology of lip, oral cavity, and pharyngeal (LOCP) cancers have been reported in the United States. This study aimed to examine recent trends in LOCP cancer mortality in the United States from 1999 to 2019.
National mortality data were extracted from CDC WONDER, 1999-2019. International Classification of Diseases Codes, 10th Revision-C00-C14, were used to identify decedents of malignant neoplasms of the lip, oral cavity, and pharynx. LOCP cancer mortality trends were assessed by fitting a Joinpoint regression model overall, and by race/ethnicity, sex, age, and US Census Region. Annual Percentage Changes (APC) were derived to estimate variations in mortality trends over time.
The age-adjusted mortality rate (AAMR) for LOCP cancers was 2.5 per 100 000 (95% CI: 2.5-2.5), equivalent to 180 532 deaths during 1999-2019. Overall mortality trends have stabilized since 2009 (APC = 0.3; 95% CI: -0.1, 0.7), but an examination by subtype revealed rising mortality trends from cancers of the lip and oral cavity (APC = 1.2; 95% CI: 0.7, 1.6) and pharynx (APC = 3.2; 95% CI: 1.7, 4.8), and declining trends in malignancies of other and ill-defined areas of the lip, oral cavity, and pharynx (APC = -2.7; 95% CI: -3.4, -2.0). Trend variations were also noted by sex, age, US Census Region, and race/ethnicity.
There are differential trends in mortality from LOCP cancers in the United States. Investigating the biological, individual, and contextual factors related to LOCP cancers would guide effective public health intervention efforts.
美国已经报道了唇、口腔和咽（LOCP）癌症的流行病学变化。本研究旨在检查 1999 年至 2019 年美国 LOCP 癌症死亡率的近期趋势。
从 CDC WONDER 提取国家死亡率数据，1999-2019 年。使用国际疾病分类第十版-C00-C14 代码来识别唇、口腔和咽恶性肿瘤的死者。通过总体拟合 Joinpoint 回归模型，以及按种族/族裔、性别、年龄和美国人口普查区评估 LOCP 癌症死亡率趋势。从死亡率趋势随时间的变化中得出年百分比变化（APC）。
LOCP 癌症的年龄调整死亡率（AAMR）为 2.5/100000（95%CI：2.5-2.5），相当于 1999-2019 年期间 180532 人死亡。自 2009 年以来，总体死亡率趋势已趋于稳定（APC=0.3；95%CI：-0.1，0.7），但通过亚型检查发现，唇癌和口腔癌（APC=1.2；95%CI：0.7，1.6）和咽癌（APC=3.2；95%CI：1.7，4.8）的死亡率呈上升趋势，以及唇、口腔和咽其他和未明确部位恶性肿瘤的死亡率呈下降趋势（APC=-2.7；95%CI：-3.4，-2.0）。性别、年龄、美国人口普查区和种族/族裔也存在趋势变化差异。
美国 LOCP 癌症的死亡率存在差异趋势。研究与 LOCP 癌症相关的生物学、个体和环境因素将指导有效的公共卫生干预措施。
