健康人体心率变异性的性别差异：荟萃分析。

Sex differences in healthy human heart rate variability: A meta-analysis.

机构信息

Department of Psychology, The Ohio State University, Columbus, OH, USA; Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre of Psychosocial Medicine, University of Heidelberg, Germany.

Department of Psychology, The Ohio State University, Columbus, OH, USA.

出版信息

Neurosci Biobehav Rev. 2016 May;64:288-310. doi: 10.1016/j.neubiorev.2016.03.007. Epub 2016 Mar 7.

DOI:10.1016/j.neubiorev.2016.03.007

PMID:26964804

Abstract

The present meta-analysis aimed to quantify current evidence on sex differences in the autonomic control of the heart, indexed by measures of heart rate variability (HRV) in healthy human subjects. An extensive search of the literature yielded 2020 titles and abstracts, of which 172 provided sufficient reporting of sex difference in HRV. Data from 63,612 participants (31,970 females) were available for analysis. Meta-analysis yielded a total of 1154 effect size estimates (k) across 50 different measures of HRV in a cumulated total of 296,247 participants. Females showed a significantly lower mean RR interval and standard deviation of RR intervals (SDNN). The power spectral density of HRV in females is characterized by significantly less total power that contains significantly greater high- (HF) and less low-frequency (LF) power. This is further reflected by a lower LF/HF ratio. Meta-regression revealed significant effects of age, respiration control and the length of recording available for analysis. Although women showed greater mean heart rate, they showed greater vagal activity indexed by HF power of HRV. Underlying mechanisms of these findings are discussed.

摘要

本荟萃分析旨在量化健康人体中心率变异性（HRV）指标的自主神经控制方面的性别差异的现有证据。文献检索得到 2020 个标题和摘要，其中 172 个提供了 HRV 性别差异的充分报告。共有 63612 名参与者（31970 名女性）的数据可用于分析。荟萃分析共产生了 50 个不同 HRV 指标的 1154 个效应量估计值（k），总计 296247 名参与者。女性的平均 RR 间隔和 RR 间隔标准差（SDNN）明显较低。女性 HRV 的功率谱密度的特点是总功率明显较小，其中高频（HF）功率明显较大，低频（LF）功率明显较小。这进一步反映在较低的 LF/HF 比值上。元回归显示年龄、呼吸控制和可用于分析的记录长度有显著影响。尽管女性的平均心率较高，但她们的 HRV 的 HF 功率显示出更大的迷走神经活动。这些发现的潜在机制正在讨论中。