De la Hera-Lazaro Cristina M, Muñoz-González Jose L, Perez Reyes Oliver, Vellido-Cotelo Rocío, Díez-Álvarez Alvaro, Muñoz-Hernando Leticia, Alvarez-Conejo Carmen, Jiménez-López Jesús S
Endometriosis Unit, Gynaecology Service, Hospital Universitario 12 de Octubre, Madrid, Spain.
Clin Med Insights Womens Health. 2016 Mar 7;9:7-11. doi: 10.4137/CMWH.S38170. eCollection 2016.
The main aim of this study is to determine the improvement in quality of life in patients who have undergone radical surgery because of severe endometriosis.
This nonrandomized interventional study (quasi experimental) was carried out between January 2009 and September 2014. A total of 46 patients with diagnosis of severe endometriosis were included. Radical surgery, including hysterectomy, was performed. Acting as their own control group, the patients were asked to fill in a validated questionnaire of quality of life [Endometriosis Health Profile-5 (EHP-5)] and a visual analog scale of pain at the moment of the preoperative visit (one month prior to surgery) and six months after the surgery.
Radical surgery for endometriosis was performed in 46 patients at our center over the period of six years. Among the patients, 73.9% of them had undergone previous surgery for endometriosis. In 82.6% of cases, a complete laparoscopic resection was carried out. Gastrointestinal tract resection was performed in 21.7%, and urinary tract resection was necessary in 8.7%. The mean age of the patients was 38.6 years. The rate of complications was 30.4%. Six months after the surgery, all items of the EHP-5 questionnaire had a lower score, which means an improvement in all aspects of quality of life related to endometriosis. The difference obtained between the scores before and after the surgery was statistically significant. The mean visual analog scale score before the surgery was 8.5, whereas it decreased to 1.4 after the surgery (P < 0.001).
Performing a radical surgery is a difficult decision to make; however, it can provide optimal results in terms of improvement of quality of life and, therefore, should be considered when conservative therapy fails.
本研究的主要目的是确定因重度子宫内膜异位症接受根治性手术的患者生活质量的改善情况。
这项非随机干预性研究(准实验性)于2009年1月至2014年9月进行。共纳入46例诊断为重度子宫内膜异位症的患者。实施了包括子宫切除术在内的根治性手术。患者作为自身的对照组,被要求在术前访视时(手术前一个月)和手术后六个月填写一份经过验证的生活质量问卷[子宫内膜异位症健康概况-5(EHP-5)]以及一份疼痛视觉模拟量表。
在六年期间,我们中心对46例患者实施了子宫内膜异位症根治性手术。其中,73.9%的患者此前曾接受过子宫内膜异位症手术。82.6%的病例进行了完全腹腔镜切除术。21.7%的患者进行了胃肠道切除术,8.7%的患者需要进行泌尿道切除术。患者的平均年龄为38.6岁。并发症发生率为30.4%。手术后六个月,EHP-5问卷的所有项目得分均较低,这意味着与子宫内膜异位症相关的生活质量的各个方面都有所改善。手术前后得分的差异具有统计学意义。术前疼痛视觉模拟量表的平均评分为8.5,而术后降至1.4(P<0.001)。
实施根治性手术是一个艰难的决定;然而,就生活质量的改善而言,它可以提供最佳效果,因此,在保守治疗失败时应予以考虑。