米团花 A-C，来自越南米团花的生物碱，基于新颖的六环骨架。
Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
University of Chinese Academy of Sciences , Beijing 100039, People's Republic of China.
出版信息
J Nat Prod. 2016 Apr 22;79(4):1203-7. doi: 10.1021/acs.jnatprod.5b01130. Epub 2016 Mar 11.
Myritonines A-C (1-3), three new alkaloids bearing an unprecedented heterohexacyclic skeleton, were isolated from Myrioneuron tonkinensis. Their structures were determined by a combination of spectroscopic data and single-crystal X-ray diffraction analysis. Compound 3 represents the first Myrioneuron alkaloid featuring a unique trans-decahydroquinoline motif and was also found to possess a rare cyano functionality. Compounds 1 and 2 showed inhibition against the hepatitis C virus in vitro.
米团花 A-C（1-3），三种新型生物碱，具有前所未有的杂六元环骨架，从米团花中分离得到。通过光谱数据和单晶 X 射线衍射分析的组合确定了它们的结构。化合物 3 代表了第一个具有独特反式十氢喹啉基序的米团花生物碱，并且还发现具有罕见的氰基功能。化合物 1 和 2 显示出对丙型肝炎病毒的体外抑制作用。
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