Jeong Tae-Dong, Lee Woochang, Yun Yeo-Min, Chun Sail, Song Junghan, Min Won-Ki
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.
Clin Biochem. 2016 Jun;49(9):713-719. doi: 10.1016/j.clinbiochem.2016.01.023. Epub 2016 Mar 9.
The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was derived mostly from Caucasian, African-American, and Hispanic populations, whereas Asian populations were excluded. The aim of this study was to develop and validate a Korean version of the CKD-EPI equation.
The study enrolled 960 individuals 18years old and older who underwent chromium-51-ethylenediaminetetraacetic-acid-based glomerular filtration rate (GFR) measurements. They were divided randomly into two groups: a development set (n=768, 80%) and a validation set (n=192, 20%). The Korean CKD-EPI equation was developed using a non-linear mixed-effect model. The performance of the equation was evaluated by calculating the bias (estimated GFR-measured GFR). The ±10% (P10) and ±30% (P30) accuracies and root mean square errors (RMSEs) of the original and Korean CKD-EPI equations were compared.
The Korean CKD-EPI equation was as follows: male, serum creatinine (Scr) ≤80μmol/L, GFR=141×(Scr/0.9)(-0.642)×(0.993)(Age); male, Scr>80μmol/L, GFR=141×(Scr/0.9)(-1.128)×(0.993)(Age); female, Scr≤62μmol/L, GFR=144×(Scr/0.7)(-0.465)×(0.993)(Age); female, Scr>62μmol/L, GFR=144×(Scr/0.7)(-1.382)×(0.993)(Age). The mean bias (mL/min/1.73m(2)) of the original CKD-EPI equation was -3.0±13.5 and that of the Korean CKD-EPI equation -2.3±13.3. The P10 and P30 of the original CKD-EPI equation were 33.9% and 82.8%; for the Korean CKD-EPI equation, the corresponding values were 35.4% and 85.9%. The RMSEs of the original and Korean CKD-EPI equations were 13.7 and 13.5, respectively.
The overall analytical performance of the Korean CKD-EPI equation was equivalent to that of the original CKD-EPI equation. The original CKD-EPI equation is therefore also valid for the Korean population.
慢性肾脏病流行病学协作组（CKD-EPI）公式主要来源于白种人、非裔美国人和西班牙裔人群，而亚洲人群被排除在外。本研究的目的是开发并验证CKD-EPI公式的韩语版本。
本研究纳入了960名18岁及以上接受基于铬-51-乙二胺四乙酸的肾小球滤过率（GFR）测量的个体。他们被随机分为两组：开发组（n=768，80%）和验证组（n=192，20%）。使用非线性混合效应模型开发韩语CKD-EPI公式。通过计算偏差（估计GFR-测量GFR）来评估该公式的性能。比较了原始CKD-EPI公式和韩语CKD-EPI公式的±10%（P10）和±30%（P30）准确率以及均方根误差（RMSE）。
韩语CKD-EPI公式如下：男性，血清肌酐（Scr）≤80μmol/L，GFR=141×(Scr/0.9)(-0.642)×(0.993)(年龄)；男性，Scr>80μmol/L，GFR=141×(Scr/0.9)(-1.128)×(0.993)(年龄)；女性，Scr≤62μmol/L，GFR=144×(Scr/0.7)(-0.465)×(0.993)(年龄)；女性，Scr>62μmol/L，GFR=144×(Scr/0.7)(-1.382)×(0.993)(年龄)。原始CKD-EPI公式的平均偏差（mL/min/1.73m²）为-3.0±13.5，韩语CKD-EPI公式的平均偏差为-2.3±13.3。原始CKD-EPI公式的P10和P30分别为33.9%和82.8%；韩语CKD-EPI公式相应的值分别为35.4%和85.9%。原始CKD-EPI公式和韩语CKD-EPI公式的RMSE分别为13.7和13.5。
韩语CKD-EPI公式的总体分析性能与原始CKD-EPI公式相当。因此，原始CKD-EPI公式对韩国人群也有效。
