Abdoli Amir
Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Med Hypotheses. 2016 Apr;89:58-62. doi: 10.1016/j.mehy.2016.02.003. Epub 2016 Feb 9.
Salt is a major mineral element that plays fundamental roles in health and disease. Excessive salt intake is a major cause of hypertension, cardiovascular disease and stroke. Miscarriage and preeclampsia are the most common pregnancy complications with multiple etiological factors, including inflammatory and autoimmune conditions. More recently, different studies indicated that excessive salt intake is involved in the development of inflammatory processes through induction of T helper-17 pathway and their inflammatory cytokines. On the other hand, several studies indicated the pivotal role of inflammation in the etiology of miscarriage, preeclampsia and adverse pregnancy outcome. Here, it is hypothesized that excessive salt intake around the time of conception or during pregnancy can trigger inflammatory processes, which consequently associated with increased risk of miscarriage, preeclampsia or adverse pregnancy outcome. Thus, this hypothesis suggests that low salt intake around the time of conception or during pregnancy can decrease the risk of miscarriage or adverse pregnancy outcome. This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.
盐是一种主要的矿物质元素，在健康与疾病中发挥着重要作用。过量摄入盐是高血压、心血管疾病和中风的主要成因。流产和先兆子痫是最常见的妊娠并发症，有多种病因，包括炎症和自身免疫性疾病。最近，不同的研究表明，过量摄入盐通过诱导辅助性T细胞17通路及其炎性细胞因子参与炎症过程的发展。另一方面，多项研究表明炎症在流产、先兆子痫和不良妊娠结局的病因中起关键作用。在此，我们推测在受孕时或怀孕期间过量摄入盐会引发炎症过程，进而增加流产、先兆子痫或不良妊娠结局的风险。因此，这一假说表明在受孕时或怀孕期间低盐摄入可降低流产或不良妊娠结局的风险。这一假说也为盐在流产和先兆子痫病因中的作用提供了新的见解。
