Sługocka Anna, Wiaderkiewicz Jan, Barski Jaroslaw J
Center for Experimental Medicine, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Cerebellum. 2017 Feb;16(1):191-202. doi: 10.1007/s12311-016-0770-4.
Since the last review paper published in Cerebellum in 2002 [1], there has been a substantial increase in the number of experiments utilizing transgenic manipulations in murine cerebellar Purkinje cells. Most of these approaches were made possible with the use of the Cre/loxP methodology and pcp2/L7 based Cre recombinase expressing transgenic mouse strains. This review aims to summarize all studies which used Purkinje cell specific transgenesis since the first use of mouse strain with Purkinje cell specific Cre expression in 2002.
自2002年在《小脑》杂志上发表上一篇综述论文[1]以来，利用转基因操作研究小鼠小脑浦肯野细胞的实验数量大幅增加。这些方法大多借助Cre/loxP技术以及基于pcp2/L7的表达Cre重组酶的转基因小鼠品系得以实现。本综述旨在总结自2002年首次使用具有浦肯野细胞特异性Cre表达的小鼠品系以来，所有使用浦肯野细胞特异性转基因技术的研究。
