Fabroni Simona, Ballistreri Gabriele, Amenta Margherita, Romeo Flora V, Rapisarda Paolo
Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca per l'Agrumicoltura e le Colture Mediterranee, Corso Savoia 190, 95024, Acireale, Italy.
J Sci Food Agric. 2016 Nov;96(14):4713-4723. doi: 10.1002/jsfa.7708. Epub 2016 Apr 13.
The phytotherapic treatment of overweight and/or moderate obesity is growing widely, thus there is a great interest towards the phenolic compounds of fruits and vegetables which may inhibit pancreatic lipase enzyme. In this study, we report the chemical composition and in vitro pancreatic lipase inhibitory activity of 13 freeze-dried anthocyanin-containing extracts of different Mediterranean plants: fruits (blood orange, pomegranate, blackberry, mulberry and sumac), citrus by-products (blood orange peel), citrus vegetative tissues (young lemon shoots); vegetables (red cabbage and violet cauliflower), legume seeds (black bean), cereals (black rice), and cereal processing by-products (black rice hull). Total phenols and anthocyanins were determined. Individual anthocyanins were identified by UHPLC-PDA-ESI/MS .
Results revealed a wide variation in the distribution of anthocyanin compounds. Blood orange and pomegranate juice extracts had the highest total anthocyanin content and exhibited the strongest inhibition of pancreatic lipase in vitro.
Inhibitory activity was positively correlated with anthocyanin content. In appropriate formulations, anthocyanin-containing extracts could find a use as anti-obesity agents. © 2016 Society of Chemical Industry.
植物疗法治疗超重和/或中度肥胖正广泛兴起，因此人们对可能抑制胰脂肪酶的水果和蔬菜中的酚类化合物极为关注。在本研究中，我们报告了13种不同地中海植物的冻干花青素提取物的化学成分及其体外胰脂肪酶抑制活性：水果（血橙、石榴、黑莓、桑椹和漆树）、柑橘类副产品（血橙皮）、柑橘类营养组织（嫩柠檬枝）；蔬菜（红甘蓝和紫花椰菜）、豆类种子（黑豆）、谷物（黑米）以及谷物加工副产品（稻壳）。测定了总酚和花青素含量。通过超高效液相色谱-光电二极管阵列-电喷雾电离/质谱法鉴定了单个花青素。
结果显示花青素化合物的分布差异很大。血橙汁提取物和石榴汁提取物的总花青素含量最高，并且在体外对胰脂肪酶的抑制作用最强。
抑制活性与花青素含量呈正相关。在合适的配方中，含花青素的提取物可作为抗肥胖剂。©2016化学工业协会。
