Hobert Oliver
Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, USA.
Curr Top Dev Biol. 2016;116:455-75. doi: 10.1016/bs.ctdb.2015.12.007. Epub 2016 Jan 14.
The analysis of the developmental programs that define many different neuron types in the nematode Caenorhabditis elegans has revealed common themes in how distinct terminal differentiation programs are controlled. Rather than being controlled in a piece-meal manner, terminal identity features of a mature neuron are often coregulated by so-called terminal selector transcription factors. Here, I summarize the terminal selector concept and emphasize core features of this concept in the C. elegans system such as coregulation of terminal effector batteries, combinatorial control mechanisms, and the coupling of initiation and maintenance of neuronal identity.
对线虫秀丽隐杆线虫中定义许多不同神经元类型的发育程序进行分析后，揭示了不同终末分化程序如何被控制的共同主题。成熟神经元的终末身份特征通常不是以零碎的方式被控制，而是由所谓的终末选择转录因子共同调节。在这里，我总结了终末选择概念，并强调了秀丽隐杆线虫系统中这一概念的核心特征，如终末效应器组的共同调节、组合控制机制以及神经元身份的起始和维持的耦合。
