Kimelman David
Department of Biochemistry, University of Washington, Seattle, Washington, USA.
Curr Top Dev Biol. 2016;116:517-36. doi: 10.1016/bs.ctdb.2015.12.008. Epub 2016 Jan 21.
A major question in developmental biology is how the early embryonic axes are established. Recent studies using different model organisms and mammalian in vitro systems have revealed the surprising result that most of the early posterior embryonic body forms from a Wnt-regulated bipotential neuromesodermal progenitor population that escapes early germ layer patterning. Part of the regulatory network that drives the maintenance and differentiation of these progenitors has recently been determined, but much remains to be discovered. This review discusses some of the common features present in all vertebrates, as well as unique aspects that different species utilize to establish their anterior-posterior (A-P) axis.
发育生物学中的一个主要问题是早期胚胎轴是如何建立的。最近使用不同模式生物和哺乳动物体外系统进行的研究揭示了一个惊人的结果，即早期胚胎后部的大部分身体由一个Wnt调节的双能神经中胚层祖细胞群体形成，该群体避开了早期胚层模式形成。最近已经确定了驱动这些祖细胞维持和分化的部分调控网络，但仍有许多有待发现。这篇综述讨论了所有脊椎动物中存在的一些共同特征，以及不同物种用于建立其前后（A-P）轴的独特方面。
