Jung Joo-Young, Lu Bo, Yoon Do-Kun, Hong Key Jo, Jang HongSeok, Liu Chihray, Suh Tae Suk
Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, Republic of Korea.
Department of Radiation Oncology, University of Florida, Gainesville, FL 32610-0385, United States.
Phys Med. 2016 Apr;32(4):562-7. doi: 10.1016/j.ejmp.2016.02.010. Epub 2016 Mar 9.
We confirmed the feasibility of using our proposed system to extract two different kinds of functional images from a positron emission tomography (PET) module by using an insertable collimator during boron neutron capture therapy (BNCT). Coincidence events from a tumor region that included boron particles were identified by a PET scanner before BNCT; subsequently, the prompt gamma ray events from the same tumor region were collected after exposure to an external neutron beam through an insertable collimator on the PET detector. Five tumor regions that contained boron particles and were located in the water phantom and in the BNCT system with the PET module were simulated with Monte Carlo simulation code. The acquired images were quantitatively analyzed. Based on the receiver operating characteristic (ROC) curves in the five boron regions, A, B, C, D, and E, the PET and single-photon images were 10.2%, 11.7%, 8.2% (center region), 12.6%, and 10.5%, respectively. We were able to acquire simultaneously PET and single prompt photon images for tumor regions monitoring by using an insertable collimator without any additional isotopes.
我们证实了在硼中子俘获疗法（BNCT）期间，通过使用可插入准直器，利用我们提出的系统从正电子发射断层扫描（PET）模块中提取两种不同功能图像的可行性。在BNCT之前，PET扫描仪识别包含硼粒子的肿瘤区域的符合事件；随后，通过PET探测器上的可插入准直器，在暴露于外部中子束后收集来自同一肿瘤区域的瞬发伽马射线事件。使用蒙特卡罗模拟代码模拟了位于水模体和带有PET模块的BNCT系统中的五个含有硼粒子的肿瘤区域。对获取的图像进行了定量分析。根据五个硼区域A、B、C、D和E中的接收器操作特征（ROC）曲线，PET图像和单光子图像的曲线下面积分别为10.2%、11.7%、8.2%（中心区域）、12.6%和10.5%。我们能够通过使用可插入准直器，在无需任何额外同位素的情况下，同时获取用于监测肿瘤区域的PET图像和单瞬发光子图像。
