利用家蚕感染模型对细菌毒力的理解。
Understanding of bacterial virulence using the silkworm infection model.
作者信息
Kaito Chikara
机构信息
Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
出版信息
Drug Discov Ther. 2016 Feb;10(1):30-3. doi: 10.5582/ddt.2016.01020.
We have used silkworms, larva of Bombyx mori, to investigate host-pathogen interactions. Silkworms have several advantages, such as high availability of a large number of animals and ease of injection of quantitative amounts of samples. Human pathogenic bacteria such as Staphylococcus aureus, Streptococcus pyogenes, or Pseudomonas aeruginosa kill silkworms. In this review, I would like to summarize our approach identifying S. aureus virulence factors by using the silkworm infection model.
我们利用家蚕（蚕蛾科昆虫家蚕的幼虫）来研究宿主与病原体之间的相互作用。家蚕具有多个优点，例如可以大量获取且易于注射定量的样本。人类病原菌，如金黄色葡萄球菌、化脓性链球菌或铜绿假单胞菌，均可导致家蚕死亡。在这篇综述中，我将总结我们利用家蚕感染模型鉴定金黄色葡萄球菌毒力因子的方法。
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