Redder Peter
Department of Microbiology and Molecular Medicine, Medical Faculty, University of Geneva, Rue Michel-Servet 1, 1211, Geneve 4, Switzerland.
Curr Genet. 2016 Nov;62(4):687-690. doi: 10.1007/s00294-016-0587-1. Epub 2016 Mar 14.
Recently a number of seminal studies have revealed that both sequence and spatio-temporal factors govern RNA decay in bacteria, which is crucial for regulation of gene expression. Ribonucleases have been described that not only exhibit sequence preferences, but also are sub-cellularly localised. Furthermore, the RNA itself is distributed in an organised manner and does not diffuse freely or randomly within the bacterial cells. Thus, even within the sub-micrometer distances of the bacterial intra-cellular space, the positions of the enzymes and their substrates are kept in check. Adding to this complexity is the secondary structure and sequence specificity that many, perhaps all, ribonucleases exhibit, including those that are responsible for "general" RNA degradation. In this review, the implications of these novel findings are discussed and specific examples from Staphylococcus aureus are analysed.
最近，一些具有开创性的研究表明，序列和时空因素都对细菌中的RNA衰变起调控作用，而这对基因表达的调节至关重要。已发现核糖核酸酶不仅表现出序列偏好性，而且在亚细胞水平上有特定定位。此外，RNA本身以一种有组织的方式分布，不会在细菌细胞内自由扩散或随机扩散。因此，即使在细菌细胞内亚微米级的距离范围内，酶及其底物的位置也受到控制。许多（也许是所有）核糖核酸酶所表现出的二级结构和序列特异性，包括那些负责“一般”RNA降解的酶，进一步增加了这种复杂性。在这篇综述中，将讨论这些新发现的意义，并分析来自金黄色葡萄球菌的具体例子。
