健康与衰老的遗传力对个人期望活动的限制。
Heritability of Health and Aging Limitations on Personally Desired Activities.
作者信息
Gurland Barry J, Page William, Small Brent, McArdle John J, Plassman Brenda L
机构信息
Columbia University Stroud Center , New York, NY, USA.
National Academy of Sciences-National Research Council Twin Registry , Tampa, FL, USA.
出版信息
Health Psychol Res. 2015 Apr 13;3(2):1981. doi: 10.4081/hpr.2015.1981. eCollection 2015 Sep 30.
The aim of this study is to estimate heritability of incident limitations on personally desired activities within the eighth decade of life. We measured self-rated ability to perform ten personally desired activities in 1606 male veteran twin pairs at baseline and four years later. At follow-up, 33% of the cohort reported more limitations in desired activities. Among twins who completed both assessments, there were no statistically significant differences in incidence rates of limitations as a function of zygosity. Sensitivity tests showed the same for change scores; and that, if cognitive impairment or death are deemed to belong among limitations of desired activities, zygosity contributed 10% to new limitations at follow-up. Maintaining personally desired activities over four years in the eighth decade is not subject to substantial genetic influence. However, if death and cognitive impairment are added to incident limitations, then genetics plays a modest role. In all cases, unique environment is the predominant influence.
本研究的目的是估计在人生第八个十年中，个人期望活动出现受限情况的遗传度。我们在基线时及四年后，对1606对男性退伍军人双胞胎进行了自我评定的、执行十项个人期望活动的能力测量。在随访时，33%的队列报告在期望活动中存在更多受限情况。在完成两项评估的双胞胎中，受限发生率作为合子性的函数，没有统计学上的显著差异。敏感性测试显示变化分数情况相同；并且，如果认知障碍或死亡被视为属于期望活动的受限情况，合子性在随访时对新的受限情况贡献了10%。在人生第八个十年中，在四年内维持个人期望活动不受显著的遗传影响。然而，如果将死亡和认知障碍添加到新出现的受限情况中，那么遗传因素起了适度作用。在所有情况下，独特环境是主要影响因素。
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