Bakour Sofiane, Sankar Senthil Alias, Rathored Jaishriram, Biagini Philippe, Raoult Didier, Fournier Pierre-Edouard
Unité de recherche sur les maladies infectieuses et tropicales émergentes (URMITE), UM 63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France.
UMR CNRS 7268 Equipe "Emergence et coévolution virale," Etablissement Français du Sang Alpes-Méditerranée et Aix-Marseille Université, 27 Boulevard Jean Moulin, 13005 Marseille.
Future Microbiol. 2016;11(3):455-66. doi: 10.2217/fmb.15.149. Epub 2016 Mar 14.
In recent years, the number of multidrug-resistant bacteria has increased rapidly and several epidemics were signaled in different regions of the world. Faced with this situation that presents a major global public health concern, the development and the use of new and rapid technologies is more than urgent. The use of the next-generation sequencing platforms by microbiologists and infectious disease specialists has allowed great progress in the medical field. Here, we review the usefulness of whole-genome sequencing for the detection of virulence and antibiotic resistance associated genes.
近年来，多重耐药菌的数量迅速增加，世界不同地区已出现多起疫情。面对这一重大全球公共卫生问题，开发和使用新型快速技术迫在眉睫。微生物学家和传染病专家对新一代测序平台的使用已在医学领域取得了巨大进展。在此，我们综述全基因组测序在检测毒力和抗生素耐药相关基因方面的作用。
