Aziz Tariq, Hangyu Hu, Naveed Muhammad, Shabbir Muhammad Aqib, Sarwar Abid, Nasbeeb Jasra, Zhennai Yang, Alharbi Metab
Key Laboratory of Geriatric Nutrition and Health Ministry of Education, Engineering and Technology Research Center of Food Additives, Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business University Haidian District, No. 11 Fucheng Road, Beijing, 100048, China.
Department of Biotechnology, Faculty of Biological Sciences, Lahore University of Biological & Applied Sciences, Lahore, Punjab, 54800, Pakistan.
Probiotics Antimicrob Proteins. 2024 Apr 13. doi: 10.1007/s12602-024-10258-8.
Due to its alleged health advantages, several uses in biotechnology and food safety, the well-known probiotic strain Lactiplantibacillus plantarum K25 has drawn interest. This in-depth investigation explores the genetic diversity, makeup, and security characteristics of the microbial genome of L. plantarum K25, providing insightful knowledge about its genotypic profile and functional characteristics. Utilizing cutting-edge bioinformatics techniques like comparative genomics, pan-genomics, and genotypic profiling was carried out to reveal the strain's multidimensional potential in various fields. The results not only add to our understanding of the genetic makeup of L. plantarum K25 but also show off its acceptability in various fields, notably in biotechnology and food safety. The explanation of evolutionary links, which highlights L. plantarum K25's aptitude as a probiotic, is one notable finding from this research. Its safety profile, which is emphasized by the absence of genes linked to antibiotic resistance, is crucial and supports its status as a promising probiotic option.
由于其所谓的健康益处、在生物技术和食品安全方面的多种用途，著名的益生菌菌株植物乳杆菌K25引起了人们的关注。这项深入研究探索了植物乳杆菌K25微生物基因组的遗传多样性、组成和安全特性，提供了关于其基因型概况和功能特征的深刻见解。利用比较基因组学、泛基因组学和基因型分析等前沿生物信息学技术，揭示了该菌株在各个领域的多维潜力。研究结果不仅增进了我们对植物乳杆菌K25基因组成的理解，还展示了其在各个领域的可接受性，特别是在生物技术和食品安全领域。对进化联系的解释突出了植物乳杆菌K25作为益生菌的能力，这是该研究的一个显著发现。其安全概况，通过缺乏与抗生素抗性相关的基因得到强调，至关重要，并支持其作为有前途的益生菌选择的地位。
