Lu B X
Zhonghua Yan Ke Za Zhi. 1989 Nov;25(6):357-9.
In a survey of 26,512 children under 12 years of age, 2 cases (0.075%) were found to have congenital intraocular coloboma. Among 193 cases of the disease from 169 families reported by 50 hospitals of 21 provinces and cities, the disease affected boys more than girls. Bilateral colobomas of the uveal tract constituted majority of the cases, and the unilateral patients showed no predilection for either eye. The colobomas mostly occurred in the lower part of the eye, involving one or more tissues, depending on the shape, scope and location of the coloboma and whether other ocular deformities existed. Colobomas of the uvea, optic nerve and macula lutea were mostly sporadic. Earlier disruptions in the embryonal cleft resulted in more serious colobomas and complicating ocular deformities.
在一项针对26512名12岁以下儿童的调查中，发现2例（0.075%）患有先天性眼内缺损。在21个省市50家医院报告的169个家庭的193例该疾病病例中，患病男孩多于女孩。双侧葡萄膜缺损占病例的大多数，单侧患者对任何一只眼睛均无偏好。缺损大多发生在眼睛下部，根据缺损的形状、范围和位置以及是否存在其他眼部畸形，可累及一个或多个组织。葡萄膜、视神经和黄斑的缺损大多为散发性。胚胎裂早期中断会导致更严重的缺损和复杂的眼部畸形。
