Yan Zihe, Yang Junjun, Hu Renjing, Hu Xichi, Chen Kong
Department of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, China.
Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
Mediators Inflamm. 2016;2016:9834020. doi: 10.1155/2016/9834020. Epub 2016 Feb 9.
Acinetobacter baumannii is a significant cause of severe hospital-acquired infections with a recent rise in multidrug-resistant infections involving traumatic wounds of military personnel. The interleukin-17 (IL-17) pathway is essential for neutrophil recruitment in response to a variety of pathogens, while the control of A. baumannii infection is known to be dependent on neutrophils. This suggests that IL-17 may play an important role in A. baumannii infection; however, this has yet to be studied. Here, we summarize the recent advances in understanding the host-pathogen interaction of A. baumannii and propose a potential role of the IL-17 pathway in generating a protective immune response.
鲍曼不动杆菌是严重医院获得性感染的重要病因，近期涉及军事人员创伤伤口的多重耐药感染有所增加。白细胞介素-17（IL-17）途径对于响应多种病原体时中性粒细胞的募集至关重要，而已知鲍曼不动杆菌感染的控制依赖于中性粒细胞。这表明IL-17可能在鲍曼不动杆菌感染中发挥重要作用；然而，这一点尚未得到研究。在此，我们总结了在理解鲍曼不动杆菌宿主-病原体相互作用方面的最新进展，并提出IL-17途径在产生保护性免疫反应中的潜在作用。
