面对多药耐药性的挑战：疫苗开发的进展与前景。
Facing the challenges of multidrug-resistant : progress and prospects in the vaccine development.
机构信息
Tropical Infectious Diseases Research and Education Center (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia.
Texas Children's Hospital Center for Vaccine Development, Baylor College of Medicine, Houston, TX, USA.
出版信息
Hum Vaccin Immunother. 2021 Oct 3;17(10):3784-3794. doi: 10.1080/21645515.2021.1927412. Epub 2021 Jun 9.
Abstract
In 2017, the World Health Organization (WHO) named as one of the three antibiotic-resistant bacterial species on its list of global priority pathogens in dire need of novel and effective treatment. With only polymyxin and tigecycline antibiotics left as last-resort treatments, the need for novel alternative approaches to the control of this bacterium becomes imperative. Vaccines against numerous bacteria have had impressive records in reducing the burden of the respective diseases and addressing antimicrobial resistance; as in the case of type . A similar approach could be appropriate for . Toward this end, several potentially protective antigens against were identified and evaluated as vaccine antigen candidates. A licensed vaccine for the bacteria, however, is still not in sight. Here we explore and discuss challenges in vaccine development against and the promising approaches for improving the vaccine development process.
摘要
2017 年，世界卫生组织（WHO）将其列为全球急需新型有效治疗方法的三种抗药性细菌之一。由于仅剩多黏菌素和替加环素两种抗生素作为最后的治疗方法，因此必须寻找新型替代方法来控制这种细菌。针对许多细菌的疫苗在减轻相关疾病负担和应对抗生素耐药性方面都取得了令人瞩目的成绩；例如，针对 型的疫苗。对于 ，类似的方法可能也是合适的。为此，已经鉴定并评估了几种针对 的潜在保护性抗原作为疫苗抗原候选物。然而，该细菌的许可疫苗仍遥遥无期。在此，我们探讨并讨论了针对 疫苗开发所面临的挑战，以及改善疫苗开发过程的有希望的方法。
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