Cappuccio F P, Siani A, Strazzullo P
Department of Internal Medicine and Metabolic Diseases, Second Medical School, University of Naples, Italy.
J Hypertens. 1989 Dec;7(12):941-6. doi: 10.1097/00004872-198912000-00003.
Over the past few years, several trials on the effect of oral calcium supplementation on blood pressure have been undertaken both in normal subjects and in patients with high blood pressure. Of these, 15 randomized, controlled studies were reviewed: 10 included patients with high blood pressure, three studied normal subjects, and two used a low-calcium diet for comparison. The 15 studies reviewed investigated a total of nearly 400 peoples. No significant evidence for a supine blood pressure-lowering effect of oral calcium supplementation was found in the trials as a whole or in those trials carried out in hypertensives only. However, a small effect on standing blood pressure was detected. Our study indicates that the overall effect of oral calcium on blood pressure, if any, is very small and confined to standing blood pressure, it is, therefore, inappropriate to recommend oral calcium supplementation for the treatment of essential hypertension.
在过去几年中，针对口服补钙对血压的影响，在正常受试者和高血压患者中都进行了多项试验。其中，对15项随机对照研究进行了综述：10项纳入了高血压患者，3项研究了正常受试者，2项采用低钙饮食作为对照。所综述的这15项研究总共调查了近400人。在整个试验中，或仅在高血压患者中进行的试验中，均未发现口服补钙有显著的仰卧位降压效果。然而，检测到对站立位血压有轻微影响。我们的研究表明，口服钙对血压的总体影响（如果有的话）非常小，且仅限于站立位血压，因此，推荐口服补钙治疗原发性高血压是不合适的。
