Stoller Michael, Stoller David, Seiler Christian
Department of Cardiology , University Hospital , Bern , Switzerland.
Open Heart. 2016 Mar 8;3(1):e000355. doi: 10.1136/openhrt-2015-000355. eCollection 2016.
This study tested the hypothesis that global physical activity and physical performance parameters are directly related to invasively obtained left superficial femoral artery (SFA) collateral flow index (CFI).
So far, the association between different measures of physical exercise activity and quantitative lower limb collateral function has not been investigated.
The primary study end point was pressure-derived CFI as obtained during a 3 min left SFA balloon occlusion. CFI is the ratio of simultaneously recorded mean SFA distal occlusive pressure divided by mean aortic pressure, both subtracted by central venous pressure. As independent variables, the items of the Global Physical Activity Questionnaire (GPAQ) and physical exercise performance (maximal workload in watts) as achieved during a bicycle or treadmill exercise test were determined. The secondary study end point was transcutaneous left calf partial oxygen pressure (PO2 in mm Hg) divided by transcutaneous PO2 at a non-ischaemic reference site as obtained simultaneously to CFI measurement.
Of the 110 study patients undergoing diagnostic coronary angiography, 79 belonged to the group without and 31 with engagement in regular intensive leisure time physical activity according to GPAQ. Left SFA CFI tended to be lower in the group without than with intensive leisure time physical activity: 0.514 ±0.141 vs 0.560 ±0.184 (p =0.0566). Transcutaneous PO2 index was associated with simultaneous left SFA CFI: CFI =018 +0.57 PO2 index; p<0.0001. Maximal physical workload was directly associated with left SFA CFI: CFI =0.40 +0.0009 maximal workload; p =0.0044.
Quantitative left SFA collateral function is directly reflected by maximal physical workload as achieved during an exercise test.
NCTO02063347.
本研究检验了以下假设，即总体身体活动和身体机能参数与通过侵入性方法获得的左股浅动脉（SFA）侧支血流指数（CFI）直接相关。
到目前为止，尚未对不同的体育锻炼活动测量指标与下肢定量侧支功能之间的关联进行研究。
主要研究终点是在3分钟左SFA球囊闭塞期间获得的压力衍生CFI。CFI是同时记录的平均SFA远端闭塞压力除以平均主动脉压力的比值，两者均减去中心静脉压。作为自变量，确定了全球身体活动问卷（GPAQ）的项目以及在自行车或跑步机运动试验期间达到的体育锻炼表现（以瓦特为单位的最大工作量）。次要研究终点是在测量CFI的同时获得的经皮左小腿部分氧分压（以毫米汞柱为单位的PO2）除以非缺血参考部位的经皮PO2。
在接受诊断性冠状动脉造影的110名研究患者中，根据GPAQ，79名属于无规律高强度休闲时间身体活动组，31名属于有规律高强度休闲时间身体活动组。无规律高强度休闲时间身体活动组的左SFA CFI往往低于有规律高强度休闲时间身体活动组：0.514±0.141 vs 0.560±0.184（p = 0.0566）。经皮PO2指数与同时测得的左SFA CFI相关：CFI = 0.18 + 0.57×PO2指数；p<0.0001。最大身体工作量与左SFA CFI直接相关：CFI = 0.40 + 0.0009×最大工作量；p = 0.0044。
运动试验期间达到的最大身体工作量直接反映了左SFA的定量侧支功能。
NCT002063347。
