联合视频耳镜-相位敏感光学相干断层扫描对中耳解剖结构和功能的研究
Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT.
作者信息
Park Jesung, Cheng Jeffrey T, Ferguson Daniel, Maguluri Gopi, Chang Ernest W, Clancy Caitlin, Lee Daniel J, Iftimia Nicusor
机构信息
Physical Sciences Inc., Andover, MA 01810, USA.
Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.
出版信息
Biomed Opt Express. 2016 Jan 5;7(2):238-50. doi: 10.1364/BOE.7.000238. eCollection 2016 Feb 1.
Abstract
We report the development of a novel otoscopy probe for assessing middle ear anatomy and function. Video imaging and phase-sensitive optical coherence tomography are combined within the same optical path. A sound stimuli channel is incorporated as well to study middle ear function. Thus, besides visualizing the morphology of the middle ear, the vibration amplitude and frequency of the eardrum and ossicles are retrieved as well. Preliminary testing on cadaveric human temporal bone models has demonstrated the capability of this instrument for retrieving middle ear anatomy with micron scale resolution, as well as the vibration of the tympanic membrane and ossicles with sub-nm resolution.
摘要
我们报告了一种用于评估中耳解剖结构和功能的新型耳镜探头的研发情况。视频成像和相敏光学相干断层扫描在同一光路中相结合。还并入了一个声音刺激通道以研究中耳功能。因此，除了可视化中耳的形态外，还能获取鼓膜和听小骨的振动幅度和频率。在尸体人类颞骨模型上的初步测试表明，该仪器能够以微米级分辨率获取中耳解剖结构，以及以亚纳米级分辨率获取鼓膜和听小骨的振动情况。
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