Hamra Matan, Shinnawi Shadi, Vaizer Mauricio Cohen, Yelin Dvir
Department of Biomedical Engineering, Technion-Israel institute of Technology, Haifa 3200003, Israel.
Department of Otolarynglogy Head and Neck Surgery, Rambam Healthcare Campus, Haifa 3109601, Israel.
Biomed Opt Express. 2020 Oct 19;11(11):6470-6479. doi: 10.1364/BOE.402097. eCollection 2020 Nov 1.
Functional imaging of the human ear is an extremely challenging task because of its minute anatomic structures and nanometer-scale motion in response to sound. Here, we demonstrate noninvasive functional imaging of the human tympanic membrane under various acoustic excitations, and identify unique vibration patterns that vary between human subjects. By combining spectrally encoded imaging with phase-sensitive spectral-domain interferometry, our system attains high-resolution functional imaging of the two-dimensional membrane surface, within a fraction of a second, through a handheld imaging probe. The detailed physiological data acquired by the system would allow measuring a wide range of clinically relevant parameters for patient diagnosis, and provide a powerful new tool for studying middle and inner ear physiology.
由于人耳微小的解剖结构以及其对声音响应的纳米级运动，对人耳进行功能成像极具挑战性。在此，我们展示了在各种声学激励下对人鼓膜进行的无创功能成像，并识别出不同受试者之间存在差异的独特振动模式。通过将光谱编码成像与相敏光谱域干涉测量相结合，我们的系统借助手持成像探头，在不到一秒的时间内实现了对二维鼓膜表面的高分辨率功能成像。该系统获取的详细生理数据将有助于测量一系列与临床相关的参数以用于患者诊断，并为研究中耳和内耳生理学提供一个强大的新工具。
