Wang Yating, Xu Dong, Yang Sihua, Xing Da
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; These authors contributed equally to this work.
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China;
Biomed Opt Express. 2016 Jan 5;7(2):279-86. doi: 10.1364/BOE.7.000279. eCollection 2016 Feb 1.
Melanoma is the most dangerous type of skin cancer with high lethal rate. Tumor thickness and tumor-associated vasculature are two key parameters for staging melanoma. Previous techniques for diagnosing melanoma have insurmountable restrictions, such as invasive, low specificity, or inaccurate depth measurement. Here we develop an integrated photoacoustic (PA) and ultrasound (US) imaging system dedicated to overcome these limitations. An integrated detector with sound-light coaxial/confocal design and flexible coupling mode is employed for the combined PA/US imaging strategy. PA imaging results enable a clear characterization of tumor angiogenesis with high resolution and high contrast. Furthermore, accurate thickness measurements of melanoma in different stages can be resolved with the simultaneously obtained PA/US image. Phantom experiments and in vivo animal experimental results demonstrate the integrated PA/US system could provide potential for noninvasive biopsy of melanoma.
黑色素瘤是最危险的皮肤癌类型，致死率很高。肿瘤厚度和肿瘤相关脉管系统是黑色素瘤分期的两个关键参数。以往诊断黑色素瘤的技术存在无法克服的局限性，如具有侵入性、特异性低或深度测量不准确等问题。在此，我们开发了一种集成光声（PA）和超声（US）成像系统，旨在克服这些局限性。采用具有声光同轴/共焦设计和灵活耦合模式的集成探测器，用于PA/US联合成像策略。PA成像结果能够以高分辨率和高对比度清晰地表征肿瘤血管生成。此外，利用同时获取的PA/US图像，可以解析不同阶段黑色素瘤的准确厚度测量。体模实验和体内动物实验结果表明，集成PA/US系统可为黑色素瘤的无创活检提供潜力。
