Fraiwan Luay, Khnouf Ruba, Mashagbeh Abdel Razaq
a Biomedical Engineering Department , Jordan University of Science & Technology , Irbid , Jordan ;
b Electrical and Computer Engineering Department , Abu Dhabi University , United Arab Emirates.
J Med Eng Technol. 2016;40(3):127-34. doi: 10.3109/03091902.2016.1148792. Epub 2016 Mar 15.
Parkinson's disease currently affects millions of people worldwide and is steadily increasing. Many symptoms are associated with this disease, including rest tremor, bradykinesia, stiffness or rigidity of the extremities and postural instability. No cure is currently available for Parkinson's disease patients; instead most medications are for treatment of symptoms. This treatment depends on the quantification of these symptoms such as hand tremor. This work proposes a new system for mobile phone applications. The system is based on measuring the acceleration from the Parkinson's disease patient's hand using a mobile cell phone accelerometer. Recordings from 21 Parkinson's disease patients and 21 healthy subjects were used. These recordings were analysed using a two level wavelet packet analysis and features were extracted forming a feature vector of 12 elements. The features extracted from the 42 subjects were classified using a neural networks classifier. The results obtained showed an accuracy of 95% and a Kappa coefficient of 90%. These results indicate that a cell phone accelerometer can accurately detect and record rest tremor in Parkinson's disease patients.
帕金森病目前影响着全球数百万人,且患病人数正在稳步增加。这种疾病有许多症状,包括静止性震颤、运动迟缓、肢体僵硬或强直以及姿势不稳。目前帕金森病患者尚无治愈方法;相反,大多数药物用于症状治疗。这种治疗取决于对这些症状的量化,比如手部震颤。这项工作提出了一种用于手机应用的新系统。该系统基于使用手机加速度计测量帕金森病患者手部的加速度。使用了21名帕金森病患者和21名健康受试者的记录。这些记录采用两级小波包分析进行分析,并提取特征,形成一个12元素的特征向量。从42名受试者提取的特征使用神经网络分类器进行分类。所得结果显示准确率为95%,卡帕系数为90%。这些结果表明,手机加速度计可以准确检测和记录帕金森病患者的静止性震颤。