Zhou Yue, Li Ya, Zhou Tong, Zheng Jie, Li Sha, Li Hua-Bin
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.
School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.
Nutrients. 2016 Mar 10;8(3):156. doi: 10.3390/nu8030156.
Liver cancer is the most common malignancy of the digestive system with high death rate. Accumulating evidences suggests that many dietary natural products are potential sources for prevention and treatment of liver cancer, such as grapes, black currant, plum, pomegranate, cruciferous vegetables, French beans, tomatoes, asparagus, garlic, turmeric, ginger, soy, rice bran, and some edible macro-fungi. These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs. This review summarizes the potential prevention and treatment activities of dietary natural products and their major bioactive constituents on liver cancer, and discusses possible mechanisms of action.
肝癌是消化系统最常见的恶性肿瘤，死亡率很高。越来越多的证据表明，许多膳食天然产物是预防和治疗肝癌的潜在来源，如葡萄、黑加仑、李子、石榴、十字花科蔬菜、菜豆、西红柿、芦笋、大蒜、姜黄、生姜、大豆、米糠以及一些可食用大型真菌。这些膳食天然产物及其活性成分可通过多种方式影响肝癌的发生和发展，如抑制肿瘤细胞生长和转移、抵御肝脏致癌物、调节免疫以及增强化疗药物的作用。本文综述了膳食天然产物及其主要生物活性成分对肝癌的潜在预防和治疗作用，并探讨了可能的作用机制。
