Department of Pharmacology, Bharat Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Pune, Maharashtra, India.
Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune, Maharashtra, India.
Nutr Cancer. 2021;73(11-12):2130-2154. doi: 10.1080/01635581.2020.1834591. Epub 2020 Oct 19.
The most common tumor linked with elevated death rates is considered the hepatocellular carcinoma (HCC), sometimes called the malignant hepatoma. The initiation and progression of HCC are triggered by multiple factors like long term alcohol consumption, metabolic disorders, fatty liver disease, hepatitis B and C infection, age, and oxidative stress. Sorafenib is the merely US Food and Drug Administration (FDA)-approved drug used to treat HCC. Several treatment methods are available for HCC therapy such as chemotherapy, immunotherapy and adjuvant therapy but they often lead to several side effects. Yet these treatment methods are not entirely adequate due to the increasing resistance to the drug and their toxicity. Many natural products help to prevent and treat HCC. A variety of pathways are associated with the prevention and treatment of HCC with herbal products and their active components. Accumulating research shows that certain natural dietary compounds are possible source of hepatic cancer prevention and treatments, such as black currant, strawberries, plum, grapes, pomegranate, cruciferous crops, tomatoes, French beans, turmeric, garlic, ginger, asparagus, and many more. Such a dietary natural products and their active constituents may prevent the production and advancement of liver cancer in many ways such as guarding against liver carcinogens, improving the effectiveness of chemotherapeutic medications, inhibiting the growth, metastasis of tumor cells, reducing oxidative stress, and chronic inflammation. The present review article represents hepatic carcinoma etiology, role of herbal products, their active constituents, and dietary natural products for the prevention and treatment of HCC along with their possible mechanisms of action.
最常见的与死亡率升高相关的肿瘤被认为是肝细胞癌（HCC），有时也称为恶性肝癌。HCC 的发生和发展是由多种因素引发的，如长期饮酒、代谢紊乱、脂肪肝疾病、乙型肝炎和丙型肝炎感染、年龄和氧化应激等。索拉非尼是唯一获得美国食品和药物管理局（FDA）批准用于治疗 HCC 的药物。HCC 的治疗方法有多种，如化疗、免疫疗法和辅助疗法，但这些方法常常会导致多种副作用。然而，由于药物耐药性和毒性的增加，这些治疗方法并不完全有效。许多天然产物有助于预防和治疗 HCC。许多天然产物及其活性成分与 HCC 的预防和治疗有关，涉及多种途径。越来越多的研究表明，某些天然膳食化合物可能是预防肝癌和治疗肝癌的来源，如黑加仑、草莓、李子、葡萄、石榴、十字花科作物、西红柿、法国豆、姜黄、大蒜、生姜、芦笋等。这些膳食天然产物及其活性成分可以通过多种方式预防肝癌的发生和发展，如防止肝致癌物、提高化疗药物的疗效、抑制肿瘤细胞的生长和转移、减轻氧化应激和慢性炎症。本文综述了 HCC 的病因学、草药产品及其活性成分的作用，以及用于预防和治疗 HCC 的膳食天然产物及其可能的作用机制。
