Wei Chunlei, Zhang Xin, Li Pengfei, Li Wei
Department of Pediatrics, The First People's Hospital of Lianyungang.
Department of Nephrology, The Fourth People's Hospital of Lianyungang.
Medicine (Baltimore). 2020 Jan;99(5):e18962. doi: 10.1097/MD.0000000000018962.
Acupoint herbal patching (AHP) is an external therapy of Traditional Chinese Medicine. This systematic review and meta-analysis sought to evaluate whether AHP during Sanfu Days has additional benefits in children with asthma.
A comprehensively electronic literature search was performed in the Cochrane Library, PubMed, Embase, CNKI, VIP, and WanFang databases from their inception to March 2019. Randomized controlled trials that evaluated the AHP during Sanfu Days treatment for pediatric asthma were included. The main outcome measures were frequency of acute asthma attack, relapse of asthma, and pulmonary function.
Eleven trials involving 882 children with asthma were identified. White mustard seed, rhizoma corydalis, and radix kansui were the most frequently used herbs. Adjunctive treatment with AHP significantly reduced the frequency of acute asthma attack (mean difference [MD] -1.62 times/year; 95% confidence intervals [CI] -2.13 to -1.11). Moreover, AHP improved the peak expiratory flow (standardized mean differences [SMD] 0.61; 95% CI 0.39-0.82) and forced expiratory volume in 1 s (SMD 0.48; 95% CI 0.31-0.66).
Application of AHP during Sanfu Days has additional benefits in reducing the frequency of acute attack and improving pulmonary function in children with asthma. However, the current findings should be interpreted with caution owing to the methodological flaws of the analyzed trials.
穴位贴敷是中医的一种外治疗法。本系统评价和荟萃分析旨在评估三伏天进行穴位贴敷对哮喘患儿是否有额外益处。
全面检索Cochrane图书馆、PubMed、Embase、中国知网、维普和万方数据库，检索时间从建库至2019年3月。纳入评估三伏天穴位贴敷治疗小儿哮喘的随机对照试验。主要结局指标为哮喘急性发作频率、哮喘复发情况及肺功能。
共纳入11项试验，涉及882例哮喘患儿。白芥子、延胡索和甘遂是最常用的药物。穴位贴敷辅助治疗显著降低了哮喘急性发作频率（平均差[MD] -1.62次/年；95%置信区间[CI] -2.13至-1.11）。此外，穴位贴敷改善了呼气峰值流速（标准化均差[SMD] 0.61；95% CI 0.39 - 0.82）和第1秒用力呼气容积（SMD 0.48；95% CI 0.31 - 0.66）。
三伏天进行穴位贴敷对降低哮喘患儿急性发作频率和改善肺功能有额外益处。然而，由于所分析试验存在方法学缺陷，目前的研究结果应谨慎解读。
