Kovalkova N A, Denisova D V, Polonskaya Ya V, Kashtanova E V
Research Institute of Internal and Preventive Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russia.
Ter Arkh. 2016;88(1):70-74. doi: 10.17116/terarkh201688170-74.
To study the incidence of respiratory symptoms and to reveal their associations with serum cotinine levels (SCL) in 25-45-year-old Novosibirsk dwellers.
The WHO respiratory symptom questionnaire and the ECRHS screening questionnaire were used for a population-based survey conducted in Novosibirsk to identify respiratory symptoms; 545 people replied to the questions available in the questionnaires. SCL was determined by enzyme immunoassay on a random subsample of 182 examinees.
The incidence of respiratory symptoms was determined among the 25-45-year-old Novosibirsk dwellers: cough (27.7%), more than 3-month cough per year (22%), sputum discharge (25%), forced respiration/wheezing in the past year (22.6%), suffocation fits in the past year (5.3%), and cough/forced respiration/stertor bouts by breathing cold air (14.9%) or contacting animals, plants, or chemical agents (16.5%). There was a significant positive correlation between SCL and the presence of cough, more than 3-month cough per year, sputum discharge, forced respiration/wheezing in the past year (compared to the examinees who did not report these symptoms). The median SCL proved to be significantly higher in the people who complained of cough, more than 3-month cough per year, sputum discharge, and forced respiration/wheezing in the past year (compared to the examinees who did not report these symptoms). The people who had a SCL of more than 3 ng/ml were ascertained to be at higher risk of cough, more than 3-month cough per year, sputum discharge, and forced respiration/wheezing in the past year than those who had a SCL of less than 3 ng/ml.
The incidence of respiratory symptoms was determined among the 25-45-year-old Novosibirsk dwellers; SCL was found to be associated with the symptoms characteristic of bronchial obstructive diseases; the expediency of using the SCL threshold of 3 ng/ml as a marker of tobacco smoking was confirmed.
研究新西伯利亚25至45岁居民的呼吸道症状发生率，并揭示其与血清可替宁水平（SCL）的关联。
采用世界卫生组织呼吸道症状问卷和欧洲社区呼吸健康调查（ECRHS）筛查问卷，在新西伯利亚进行基于人群的调查以确定呼吸道症状；545人回答了问卷中的问题。通过酶免疫测定法对182名受检者的随机子样本测定SCL。
确定了新西伯利亚25至45岁居民的呼吸道症状发生率：咳嗽（27.7%）、每年咳嗽超过3个月（22%）、咳痰（25%）、过去一年出现呼吸急促/喘息（22.6%）、过去一年出现窒息发作（5.3%），以及因吸入冷空气（14.9%）或接触动物、植物或化学制剂（16.5%）而出现咳嗽/呼吸急促/喘鸣发作。SCL与咳嗽、每年咳嗽超过3个月、咳痰、过去一年出现呼吸急促/喘息（与未报告这些症状的受检者相比）之间存在显著正相关。事实证明，在抱怨咳嗽、每年咳嗽超过3个月、咳痰以及过去一年出现呼吸急促/喘息的人群中，SCL中位数显著高于未报告这些症状的受检者。与SCL低于3 ng/ml的人群相比，SCL高于3 ng/ml的人群在过去一年出现咳嗽、每年咳嗽超过3个月、咳痰以及呼吸急促/喘息的风险更高。
确定了新西伯利亚25至45岁居民的呼吸道症状发生率；发现SCL与支气管阻塞性疾病的特征性症状相关；证实了将3 ng/ml的SCL阈值用作吸烟标志物的合理性。
