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[三七皂苷对心血管系统的结构及生物学作用]

[Structure and biological action on cardiovascular systems of saponins from Panax notoginseng].

作者信息

Li Juan, Wang Ru-feng, Yang Li, Wang Zheng-tao

出版信息

Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(17):3480-7.

PMID:26978992
Abstract

Notoginseng Radix et Rhizoma (Sanqi), the underground part of Panax notoginseng (Burk.) F. H. Chen (Araliaceae) is commonly used in Chinese medicine for treatment of haemorrhage, haemostasis, swelling, etc. The aerial part including leaves, flowers and fruits are also applied for similar functions. Triterpenoid saponins are considered to be responsible for the biological activities of Sanqi. Up to date, more than 100 saponins have been isolated from theroots, rhizomes, leaves, flowers and fruits of P. notoginseng. The reported saponins can be classified into protopanaxadiol (PPD), protopanaxatriol (PPT), C17 side-chain varied and other types, according to the skeletons of the aglycons. The present review summarizes the saponins isolated from P. notoginseng and their distribution in different medicinal organs, as well as the pharmacological actions on cardiovascular system.

摘要

三七,五加科植物三七(Panax notoginseng (Burk.) F. H. Chen)的地下部分,常用于中药中治疗出血、止血、肿胀等。地上部分包括叶、花和果实也具有类似功能。三萜皂苷被认为是三七生物活性的主要成分。迄今为止,已从三七的根、根茎、叶、花和果实中分离出100多种皂苷。根据苷元骨架,报道的皂苷可分为原人参二醇(PPD)、原人参三醇(PPT)、C17侧链变化型和其他类型。本综述总结了从三七中分离出的皂苷及其在不同药用部位的分布,以及对心血管系统的药理作用。

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[Structure and biological action on cardiovascular systems of saponins from Panax notoginseng].[三七皂苷对心血管系统的结构及生物学作用]
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