Herrmann Inge K, Beck-Schimmer Beatrice, Schumacher Christoph M, Gschwind Sabrina, Kaech Andres, Ziegler Urs, Clavien Pierre-Alain, Günther Detlef, Stark Wendelin J, Graf Rolf, Schlegel Andrea A
Institute of Anesthesiology, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.
Institute of Physiology & Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Nanomedicine (Lond). 2016 Apr;11(7):783-96. doi: 10.2217/nnm.16.22. Epub 2016 Mar 16.
While carbon-encapsulated iron carbide nanoparticles exhibit strong magnetic properties appealing for biomedical applications, potential side effects of such materials remain comparatively poorly understood. Here, we assess the effects of iron-based nanoparticles in an in vivo long-term study in mice with observation windows between 1 week and 1 year.
MATERIALS & METHODS: Functionalized (PEG or IgG) carbon-encapsulated platinum-spiked iron carbide nanoparticles were injected intravenously in mice (single or repeated dose administration).
One week after administration, magnetic nanoparticles were predominantly localized in organs of the reticuloendothelial system, particularly the lung and liver. After 1 year, particles were still present in these organs, however, without any evident tissue alterations, such as inflammation, fibrosis, necrosis or carcinogenesis. Importantly, reticuloendothelial system organs presented with normal function.
This long-term exposure study shows high in vivo compatibility of intravenously applied carbon-encapsulated iron nanoparticles suggesting continuing investigations on such materials for biomedical applications.
虽然碳包裹碳化铁纳米颗粒具有吸引人的强磁性，适用于生物医学应用，但此类材料的潜在副作用仍相对了解较少。在此，我们在一项对小鼠进行的体内长期研究中评估铁基纳米颗粒的影响，观察期为1周和1年。
将功能化（聚乙二醇或免疫球蛋白G）的碳包裹掺铂碳化铁纳米颗粒静脉注射到小鼠体内（单次或重复给药）。
给药1周后，磁性纳米颗粒主要定位于网状内皮系统的器官，尤其是肺和肝脏。1年后，颗粒仍存在于这些器官中，然而，没有任何明显的组织改变，如炎症、纤维化、坏死或致癌作用。重要的是，网状内皮系统器官功能正常。
这项长期暴露研究表明静脉注射的碳包裹铁纳米颗粒在体内具有高度兼容性，这表明对此类材料在生物医学应用方面需继续进行研究。
