Kim Jeong Hong, Chang Jung Hyun, Choi Hyun Seung, Kim Hyun Jik, Kang Ju Wan
1Department of Otorhinolaryngology, Jeju National University School of Medicine, Jeju, Korea.
Am J Rhinol Allergy. 2016 Mar-Apr;30(2):e48-52. doi: 10.2500/ajra.2016.30.4302.
Results of several studies showed that blood lead concentration is positively associated with total immunoglobulin E (IgE) value. However, no study has investigated whether allergic sensitization could be responsible for the association between lead exposure and total IgE value.
We investigated whether there was difference in the association between lead exposure and the total IgE value, depending on the presence or absence of Dermatophagoides farinae sensitization.
We used data obtained from the Korea National Health and Nutrition Examination Survey. Serum levels of heavy metals, such as mercury, cadmium, and lead, were measured. Total and D. farinae specific IgE levels were measured, and the urinary cotinine level was investigated. Information about sex, age, body mass index, and household income were also obtained. We analyzed the association between serum lead and total IgE levels, after adjusting other variables.
In an multivariate linear regression analysis, only the serum concentration of lead among the three heavy metals was positively associated with logarithmic transformed total IgE (coefficient [B], 0.026 [95% confidence interval {CI}], 0.008-0.044). When we performed the same analysis on groups divided by allergic D. farinae sensitization status, we found a significant positive association between serum lead and logarithmic transformed total IgE values in subjects with D. farinae sensitization (B, 0.043 [95% CI, 0.014-0.071]) but not in subjects without D. farinae sensitization (B, 0.015 [95% CI, -0.008 to 0.039]).
A positive association between the serum lead and total IgE levels was statistically significant in subjects with D. farinae sensitization, which indicated that the immunologic effects of lead exposure may be greater in people with allergic sensitization.
多项研究结果表明，血铅浓度与总免疫球蛋白E（IgE）值呈正相关。然而，尚无研究调查过敏致敏是否可能是铅暴露与总IgE值之间关联的原因。
我们调查了根据粉尘螨致敏情况，铅暴露与总IgE值之间的关联是否存在差异。
我们使用了韩国国家健康与营养检查调查的数据。测量了汞、镉和铅等重金属的血清水平。测量了总IgE和粉尘螨特异性IgE水平，并调查了尿可替宁水平。还获取了有关性别、年龄、体重指数和家庭收入的信息。在调整其他变量后，我们分析了血清铅与总IgE水平之间的关联。
在多变量线性回归分析中，三种重金属中只有血清铅浓度与对数转换后的总IgE呈正相关（系数[B]，0.026 [95%置信区间{CI}]，0.008 - 0.044）。当我们对根据粉尘螨过敏致敏状态分组的人群进行相同分析时，我们发现粉尘螨致敏的受试者血清铅与对数转换后的总IgE值之间存在显著正相关（B，0.043 [95% CI，0.014 - 0.071]），而在无粉尘螨致敏的受试者中则无此相关性（B，0.015 [95% CI，-0.008至0.039]）。
在粉尘螨致敏的受试者中，血清铅与总IgE水平之间的正相关具有统计学意义，这表明过敏致敏人群中铅暴露的免疫效应可能更大。
