Kang Ju Wan, Kim Jeong Hong, Yoon Joo-Heon, Kim Chang-Hoon
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Departement of Otorhinolaryngology, Jeju National University School of Medicine, Jeju, Republic of Korea.
Int J Pediatr Otorhinolaryngol. 2014 May;78(5):817-20. doi: 10.1016/j.ijporl.2014.02.021. Epub 2014 Feb 26.
Vitamin D has immune modulatory functions, and thus its relationship with allergic disease has been evaluated in a number of studies. However, no concrete link between serum IgE level and vitamin D has been established. Thus, the purpose of study was to confirm the association of serum vitamin D level with the serum IgE (total and Dematophagoides farinae specific IgE) in Korean adolescents.
A total of 365 subjects between 10 and 18 years of age were enrolled through the Korea National Health and Nutrition Examination Survey (KNHANES). Serum levels of vitamin D, total IgE, and Dermatophagoides farinae (Df) specific IgE were measured, and data for potential confounding variables were collected. Multivariate regression analyses were used to determine the independent effects of these variables.
Levels of both total and Df specific IgE were positively correlated with serum concentration of vitamin D (Spearman's rho (R)=0.126, p=0.016; R=0.152, p=0.004, respectively). These results were confirmed by multivariate linear regression analysis after adjusting for sex, age, and body mass index (coefficient (B): 10.45 95% confidence interval (CI): 0.59-20.31; B: 1.06, 95% CI: 0.31-1.80, respectively). And, the association between serum vitamin D and IgE showed the different results depending on the presence or absence of Df sensitization.
Serum concentration of vitamin D was positively associated with levels of both total IgE and Df-specific IgE in Korean adolescents.
维生素D具有免疫调节功能，因此多项研究对其与过敏性疾病的关系进行了评估。然而，血清IgE水平与维生素D之间尚未确立具体联系。因此，本研究旨在证实韩国青少年血清维生素D水平与血清IgE（总IgE和粉尘螨特异性IgE）之间的关联。
通过韩国国家健康与营养检查调查（KNHANES）招募了365名10至18岁的受试者。测量血清维生素D、总IgE和粉尘螨（Df）特异性IgE水平，并收集潜在混杂变量的数据。采用多变量回归分析来确定这些变量的独立影响。
总IgE和Df特异性IgE水平均与血清维生素D浓度呈正相关（斯皮尔曼等级相关系数（R）分别为0.126，p = 0.016；R = 0.152，p = 0.004）。在对性别、年龄和体重指数进行校正后，多变量线性回归分析证实了这些结果（系数（B）：10.45，95%置信区间（CI）：0.59 - 20.31；B：1.06，95%CI：0.31 - 1.80）。而且，血清维生素D与IgE之间的关联根据是否存在Df致敏而呈现不同结果。
韩国青少年血清维生素D浓度与总IgE水平和Df特异性IgE水平均呈正相关。
