Graduate School of Urban Public Health, University of Seoul, Seoul, Republic of Korea.
Department of Health Convergence, Ewha Womans University, Seoul, Republic of Korea.
Osteoarthritis Cartilage. 2020 Apr;28(4):462-467. doi: 10.1016/j.joca.2020.02.830. Epub 2020 Feb 28.
The objective of this study was to examine whether osteoarthritis (OA) in the knees was associated with total immunoglobulin E (IgE), allergen-specific IgE, or allergic sensitizations in a nationally representative population.
The study population comprised of 785 adults aged 50 years or more in the Korea National Health and Nutrition Examination Survey 2010. OA was diagnosed as radiographic (rOA) and symptomatic osteoarthritis (sxOA). We performed multivariable logistic regression analyses to investigate relationships of OA in a knee with serum total IgE, allergen (Dermatophagoides farinae, cockroach, and dog allergens)-specific IgE, and allergic sensitizations.
Participants with the highest tertile of the total IgE had 92% and 242% increased risk of knee rOA and sxOA, respectively. Those with D. farinae-specific IgE had 2.2 times increased risk of knee sxOA compared to the lowest tertile. Participants with high total IgE (>150kU/L) had a 60% increased risk of knee rOA. Those with D. farinae-specific sensitization (>0.35kU/L) had 2.0 times increased risk of knee sxOA in compared to those without sensitization. Population-attributable fractions of knee rOA caused by high total IgE and knee sxOA caused by D. farinae-specific sensitization were 9.8% and 15.3%, respectively.
Total IgE and D. farinae-specific IgE were significantly associated with OA in knees of Korean adults. High total IgE and D. farinae-specific sensitization were also associated with their OA.
本研究旨在探讨膝关节骨关节炎（OA）是否与总免疫球蛋白 E（IgE）、过敏原特异性 IgE 或过敏敏化有关。
本研究人群为 2010 年韩国国家健康和营养检查调查中 785 名年龄在 50 岁及以上的成年人。OA 诊断为影像学（rOA）和症状性骨关节炎（sxOA）。我们进行了多变量逻辑回归分析，以研究膝关节 OA 与血清总 IgE、过敏原（粉尘螨、蟑螂和狗过敏原）特异性 IgE 和过敏敏化的关系。
总 IgE 最高三分位的参与者患膝关节 rOA 和 sxOA 的风险分别增加了 92%和 242%。与最低三分位相比，对尘螨特异性 IgE 有 2.2 倍增加的膝关节 sxOA 风险。总 IgE 较高（>150kU/L）的参与者患膝关节 rOA 的风险增加了 60%。与无过敏敏化相比，对尘螨特异性敏化（>0.35kU/L）的参与者患膝关节 sxOA 的风险增加了 2.0 倍。由高总 IgE 引起的膝关节 rOA 和由尘螨特异性敏化引起的膝关节 sxOA 的人群归因分数分别为 9.8%和 15.3%。
总 IgE 和尘螨特异性 IgE 与韩国成年人膝关节 OA 显著相关。高总 IgE 和尘螨特异性致敏也与 OA 相关。
