Sukumaran Renu, Somanathan Thara, Kattoor Jayasree
Regional Cancer Centre, Trivandrum, Kerala, India.
J Oral Maxillofac Pathol. 2015 Sep-Dec;19(3):371-4. doi: 10.4103/0973-029X.174626.
Odontogenic ghost cell carcinoma (OGCC) is an exceptionally rare malignant odontogenic epithelial tumor. It is characterized by ameloblastic-like islands of epithelial cells with aberrant keratinization in the form of ghost cells with varying amounts of dysplastic dentin. Malignant histological characteristics include infiltration, cellular pleomorphism, numerous mitosis and necrosis. Its biological behavior varies from slow-growing locally invasive lesions to rapidly growing highly aggressive tumors. OGCC metastasizing to distant sites is extremely rare. Only three cases of metastasis have been reported in literature. We are reporting the case of a 54-year-old male patient who presented with tender swelling in the malar region. Histopathological examination revealed OGCC and he received postoperative radiotherapy. Two years later, he presented with a lung mass. Biopsy from the lung lesion showed the same morphology as that of maxillary tumor with scattered ghost cells. This case points to the aggressive behavior of OGCC and its metastatic potential. It also highlights the need for long-term follow-up of these patients.
牙源性影细胞癌（OGCC）是一种极为罕见的恶性牙源性上皮肿瘤。其特征为上皮细胞呈成釉细胞样岛状排列，伴有异常角化，形成影细胞，并伴有不同程度的发育异常牙本质。恶性组织学特征包括浸润、细胞多形性、大量有丝分裂和坏死。其生物学行为从生长缓慢的局部浸润性病变到生长迅速的高度侵袭性肿瘤不等。OGCC转移至远处部位极为罕见。文献中仅报道了3例转移病例。我们报告一例54岁男性患者，其颧部出现压痛性肿胀。组织病理学检查显示为OGCC，患者接受了术后放疗。两年后，他出现肺部肿块。肺部病变活检显示与上颌肿瘤形态相同，可见散在的影细胞。该病例表明OGCC具有侵袭性生物学行为及其转移潜能。它还强调了对这些患者进行长期随访的必要性。
