Lu Y, Mock D, Takata T, Jordan R C
University of Toronto and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Ontario, Canada.
J Oral Pathol Med. 1999 Aug;28(7):323-9. doi: 10.1111/j.1600-0714.1999.tb02048.x.
Only 12 odontogenic ghost cell carcinomas (OGCC) have been reported in the English language literature to date. This article reports four additional cases of this rare odontogenic tumour and examines them in relation to those previously described. Judging from the number of published cases, the OGCC is more prevalent in Asians than other racial groups, occurs more often in the maxilla than the mandible, and is slightly more common in males than females. Histologically, elements of a benign calcifying odontogenic cyst (COC) can be identified in all the malignant variants, either separated or admixed with the malignant epithelial component. The latter can consist of either small basaloid cells or large epithelial cells. Despite the differing histological presentations, the biological behavior of the tumour is unpredictable, with some cases characterized by relatively indolent growth and others by a locally aggressive and potentially fatal course. The tumour apparently arises most often from malignant transformation of a preexisting benign COC, although it may also develop from other odontogenic tumours.
迄今为止，英文文献中仅报道了12例牙源性影细胞癌（OGCC）。本文报告了另外4例这种罕见的牙源性肿瘤，并将它们与先前描述的病例进行了对比研究。从已发表病例的数量来看，OGCC在亚洲人中比在其他种族中更为常见，在上颌骨中比在下颌骨中更常发生，且在男性中比在女性中略为多见。在组织学上，在所有恶性变体中均可识别出良性钙化牙源性囊肿（COC）的成分，它们与恶性上皮成分可分离或混合存在。后者可由小的基底样细胞或大的上皮细胞组成。尽管组织学表现不同，但肿瘤的生物学行为是不可预测的，有些病例表现为相对惰性的生长，而另一些病例则表现为局部侵袭性且可能致命的病程。该肿瘤显然最常起源于先前存在的良性COC的恶性转化，尽管它也可能由其他牙源性肿瘤发展而来。
