利用斑马鱼深入了解肾脏干细胞的发育与再生
Insights into kidney stem cell development and regeneration using zebrafish.
作者信息
Drummond Bridgette E, Wingert Rebecca A
机构信息
Bridgette E Drummond, Rebecca A Wingert, Department of Biological Sciences, Center for Zebrafish Research, Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, United States.
出版信息
World J Stem Cells. 2016 Feb 26;8(2):22-31. doi: 10.4252/wjsc.v8.i2.22.
Kidney disease is an escalating global health problem, for which the formulation of therapeutic approaches using stem cells has received increasing research attention. The complexity of kidney anatomy and function, which includes the diversity of renal cell types, poses formidable challenges in the identification of methods to generate replacement structures. Recent work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney, known as nephrons, following acute injury. Here, we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology, which may uncover important clues for regenerative medicine.
肾脏疾病是一个日益严重的全球健康问题，针对该疾病利用干细胞制定治疗方法已受到越来越多的研究关注。肾脏解剖结构和功能的复杂性，包括肾细胞类型的多样性，给生成替代结构方法的识别带来了巨大挑战。最近利用斑马鱼开展的研究表明，在急性损伤后，它们具有很高的再生肾脏完整工作单元（即肾单位）的能力。在此，我们讨论这些发现，并探索如何进一步利用斑马鱼来更深入地从分子层面理解肾干细胞生物学，这可能会为再生医学揭示重要线索。
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