Zare-Zardini H, Amiri A, Shanbedi M, Taheri-Kafrani A, Sadri Z, Ghanizadeh F, Neamatzadeh H, Sheikhpour R, Keyvani Boroujeni F, Masoumi Dehshiri R, Hashemi A, Aminorroaya M M, Dehgahnzadeh M R, Shahriari Sh
Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran; Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
Iran J Ped Hematol Oncol. 2015;5(4):233-48. Epub 2015 Dec 10.
Despite development of new approaches for the treatment of cancer disease, it is the second cause of mortality in world. Annually, 30000 persons die in Iran due to cancer diseases. Eighty percent of cancer patients are children which about 50% children lead to death. Given the high rate of cancer-related death, the new approaches for prevention, control, early diagnosis, and treatment of this disease seem necessary. Investigation of new strategies is the major challenge for scientists at recent century. Nanotechnology as a new scientific field with novel and small compounds utilized different fields over the past ten years especially in medicine. This science has come to the forefront in the areas of medical diagnostics, imaging, and therapeutic scheduls. Therefore, it has the potential applications for cancer detection and therapy. This review will discuss the therapeutic applications of different nano-materials in diagnosis, imaging, and delivery of therapeutic agents for the treatment of cancer with a major focus on their applications for the treatment of cancer and cancer- related diseases in children. The advancements in established nanoparticle technologies such as liposomes, polymer micelles, and functionalization regarding tumor targeting and controlled release strategies as well as drug delivery were discussed. It will also review the blood toxicity of used nanostructures.
尽管癌症治疗出现了新方法，但它仍是全球第二大致死原因。在伊朗，每年有3万人死于癌症。80%的癌症患者是儿童，其中约50%的儿童会死亡。鉴于癌症相关死亡率很高，预防、控制、早期诊断和治疗这种疾病的新方法似乎很有必要。研究新策略是近一个世纪以来科学家面临的主要挑战。纳米技术作为一个新的科学领域，拥有新型的小化合物，在过去十年中被应用于不同领域，尤其是医学领域。这门科学在医学诊断、成像和治疗方案等领域已处于前沿。因此，它在癌症检测和治疗方面具有潜在应用价值。本综述将讨论不同纳米材料在癌症诊断、成像和治疗药物递送方面的治疗应用，主要关注它们在儿童癌症及癌症相关疾病治疗中的应用。文中还讨论了已有的纳米颗粒技术（如脂质体、聚合物胶束）的进展，以及在肿瘤靶向、控释策略和药物递送方面的功能化。此外，还将综述所用纳米结构的血液毒性。
