Bhaumik Soumyadeep, Karimkhani Chante, Czaja Christopher A, Williams Hywel C, Rani Monica, Nasser Mona, Boyers Lindsay N, Dmitruk Sergei, Dellavalle Robert P
Journal of Family Medicine and Primary Care, India; Cochrane Priority Setting Methods Group, United Kingdom.
College of Physicians and Surgeons, Columbia University New York, USA.
J Family Med Prim Care. 2015 Oct-Dec;4(4):507-13. doi: 10.4103/2249-4863.174266.
Neglected tropical diseases (NTDs) impact disadvantaged populations in resource-scarce settings. Availability of synthesized evidence is paramount to end this disparity. The aim of the study was to determine whether NTD systematic reviews or protocols in the Cochrane Database of Systematic Reviews (CDSR) reflect disease burden.
Two authors independently searched the CDSR for reviews/protocols regarding the NTDs diseases. Each review or protocol was classified to a single NTD category. Any discrepancy was solved by consensus with third author. NTD systematic review or protocol from CDSR were matched with disability-adjusted life year (DALY) metrics from the Global Burden of Disease 2010 Study. Spearman's rank correlation coefficient and associated P values were used to assess for correlation between the number of systematic reviews and protocols and the %2010 DALY associated with each NTD.
Overall, there was poor correlation between CDSR representation and DALYs. Yellow fever, echinococcus, onchocerciasis, and schistosomiasis representation was well-aligned with DALY. Leprosy, trachoma, dengue, leishmaniasis, and Chagas disease representation was greater, while cysticercosis, human African trypanosomiasis, ascariasis, lymphatic filariasis, and hookworm representation was lower than DALY. Three of the 18 NTDs had reviews/protocols of diagnostic test accuracy.
Our results indicate the need for increased prioritization of systematic reviews on NTDs, particularly diagnostic test accuracy reviews.
被忽视的热带病（NTDs）对资源匮乏地区的弱势群体产生影响。综合证据的可得性对于消除这种差距至关重要。本研究的目的是确定Cochrane系统评价数据库（CDSR）中的NTD系统评价或方案是否反映了疾病负担。
两位作者独立检索CDSR中有关NTDs疾病的评价/方案。每项评价或方案被归类到单一的NTD类别。任何差异通过与第三位作者达成共识来解决。将CDSR中的NTD系统评价或方案与《2010年全球疾病负担研究》中的伤残调整生命年（DALY）指标进行匹配。使用Spearman等级相关系数和相关的P值来评估系统评价和方案的数量与每种NTD相关的2010年DALY百分比之间的相关性。
总体而言，CDSR中的呈现与DALYs之间的相关性较差。黄热病、棘球蚴病、盘尾丝虫病和血吸虫病的呈现与DALY高度一致。麻风病、沙眼、登革热、利什曼病和恰加斯病的呈现较多，而囊尾蚴病、非洲人类锥虫病、蛔虫病、淋巴丝虫病和钩虫病的呈现低于DALY。18种NTD中有3种有诊断试验准确性的评价/方案。
我们的结果表明需要提高对NTDs系统评价的优先级，特别是诊断试验准确性评价。
