Karimkhani Chante, Trikha Ritika, Aksut Baran, Jones Trevor, Boyers Lindsay N, Schlichte Megan, Pederson Hannah, Okland Tyler, DiGuiseppi Carolyn, Nasser Mona, Naghavi Mohsen, Vos Theo, Yoong Sze Lin, Wolfenden Luke, Murray Christopher J L, Dellavalle Robert P
Columbia University College of Physicians and Surgeons, New York, NY, USA.
Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Injury. 2016 May;47(5):1151-7. doi: 10.1016/j.injury.2015.12.019. Epub 2016 Jan 12.
Burden of disease should impact research prioritisation.
To analyse the Cochrane Database of Systematic Reviews (CDSR) and determine whether systematic reviews and protocols accurately represent disease burden, as measured by disability-adjusted life years (DALYs) from the Global Burden of Disease (GBD) 2010 Study.
Two investigators collected GBD disability metrics for 12 external causes of injury in the GBD 2010 Study. These external causes were then assessed for systematic review and protocol representation in CDSR. Data was collected during the month of April 2015. There were no study participants aside from the researchers. Percentage of total 2010 DALYs, 2010 DALY rank, and median DALY percent change from 1990 to 2010 of the 12 external causes of injury were compared with CDSR representation of systematic reviews and protocols. Data were analysed for correlation using Spearman rank correlation.
Eleven of the 12 causes were represented by at least one systematic review or protocol in CDSR; the category collective violence and legal intervention had no representation in CDSR. Correlation testing revealed a strong positive correlation that was statistically significant. Representation of road injury; interpersonal violence; fire, heat, and hot substances; mechanical forces; poisonings, adverse effect of medical treatment, and animal contact was well aligned with respect to DALY. Representation of falls was greater compared to DALY, while self-harm, exposure to forces of nature, and other transport injury representation was lower compared to DALY.
CDSR representation of external causes of injury strongly correlates with disease burden. The number of systematic reviews and protocols was well aligned for seven out of 12 causes of injury. These results provide high-quality and transparent data that may guide future prioritisation decisions.
疾病负担应影响研究优先级。
分析Cochrane系统评价数据库（CDSR），并确定系统评价和方案是否准确反映疾病负担，疾病负担采用全球疾病负担（GBD）2010研究中的伤残调整生命年（DALYs）来衡量。
两名研究者收集了GBD 2010研究中12种外部伤害原因的GBD伤残指标。然后评估这些外部原因在CDSR中的系统评价和方案呈现情况。数据收集于2015年4月。除研究人员外，没有研究参与者。将12种外部伤害原因在2010年DALYs总数中的占比、2010年DALY排名以及从1990年到2010年的DALY百分比中位数变化与CDSR中系统评价和方案的呈现情况进行比较。使用Spearman等级相关性分析数据的相关性。
12种原因中的11种在CDSR中至少有一项系统评价或方案呈现；“集体暴力和法律干预”类别在CDSR中没有呈现。相关性测试显示存在强烈的正相关，且具有统计学意义。道路伤害、人际暴力、火灾、热和热物质、机械力、中毒、医疗不良影响和动物接触方面的呈现与DALY情况吻合良好。跌倒的呈现相对于DALY更多，而自残、暴露于自然力和其他交通伤害的呈现相对于DALY更低。
CDSR中外部伤害原因的呈现与疾病负担密切相关。12种伤害原因中有7种的系统评价和方案数量吻合良好。这些结果提供了高质量且透明的数据，可能会指导未来的优先级决策。
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