Rocha Eduardo P C
Microbial Evolutionary Genomics, Institut Pasteur, Paris, France.
Centre National de la Recherche Scientifique (CNRS), UMR3525, Paris, France.
PLoS Biol. 2016 Mar 17;14(3):e1002417. doi: 10.1371/journal.pbio.1002417. eCollection 2016 Mar.
The diversification of prokaryotes is accelerated by their ability to acquire DNA from other genomes. However, the underlying processes also facilitate genome infection by costly mobile genetic elements. The discovery that cells can uptake DNA by natural transformation was instrumental to the birth of molecular biology nearly a century ago. Surprisingly, a new study shows that this mechanism could efficiently cure the genome of mobile elements acquired through previous sexual exchanges.
原核生物通过从其他基因组获取DNA的能力加速了其多样化。然而,这些潜在过程也促进了代价高昂的可移动遗传元件对基因组的感染。近一个世纪前,细胞可通过自然转化摄取DNA这一发现对分子生物学的诞生起到了重要作用。令人惊讶的是,一项新研究表明,这种机制可以有效地清除通过先前有性交换获得的可移动元件的基因组。