Baev V I, Drukina M A
Ukr Biokhim Zh (1978). 1978 Mar-Apr;50(2):150-4.
Cooling of rats under conditions of hypercapina and hypoxia induced no changes in the content of adenine nucleotides in the brain and skeletal muscles and decreased their concentration in the liver and myocardium. The content of creatine phosphate increased in the brain, but had no changes in the other tissues. 48 hours after cooling the amount of adenine nucleotides in the brain was higher as compared with the initial values, that was due to an increase in the ATP concentration; in the other tissues the contents of adenine nucleotides did not differ from that of the intact rats. The repeated action (48 hours after the first influences) caused no changes in the contents of adenine nucleotides in skeletal muscles and decreased them in the myocardium and liver. In the brain their amount and the content of creatinephosphate were increased as related to the intact rats. In the brain and myocardium the level of NADPH decreased after the first action and 48 hours after impact it restored up to the inital values. After repeated impact the level of NADPH in the brain restored up to initial values, in the myocardium it was increased.
在高碳酸血症和缺氧条件下对大鼠进行降温处理，并未引起大脑和骨骼肌中腺嘌呤核苷酸含量的变化，却降低了肝脏和心肌中腺嘌呤核苷酸的浓度。磷酸肌酸的含量在大脑中增加，但在其他组织中没有变化。降温48小时后，大脑中腺嘌呤核苷酸的量比初始值更高，这是由于ATP浓度增加所致；在其他组织中，腺嘌呤核苷酸的含量与未处理的大鼠没有差异。重复作用（第一次处理后48小时）并未引起骨骼肌中腺嘌呤核苷酸含量的变化，却降低了心肌和肝脏中腺嘌呤核苷酸的含量。与未处理的大鼠相比，大脑中腺嘌呤核苷酸的量和磷酸肌酸的含量增加。在大脑和心肌中，第一次处理后NADPH水平下降，处理后48小时恢复到初始值。重复处理后，大脑中NADPH水平恢复到初始值，心肌中的NADPH水平升高。
